@misc{oai:repo.qst.go.jp:00063633,
 author = {長谷川, 純崇 and 古川, 高子 and 佐賀, 恒夫 and 長谷川 純崇 and 古川 高子 and 佐賀 恒夫},
 month = {Oct},
 note = {The recent success with small fish as an animal model of cancer has attracted cancer researchers'attention because of the capability of directly visualizing tumor cells in vivo. Here we report a unique medaka model, in which we are able to observe various cell behaviors of in vivo transplanted tumor cells such as cell proliferation and metastasis. We established medaka melanoma (MM) cells stably expressing green fluorescence protein (GFP) and transplanted them into non-irradiated and irradiated medaka. The tumor cells were grown at the injection sites 
in medaka, and the spatiotemporal changes were visualized under fluorescence stereoscopic microscope with a cellular level-resolution, even at a single cell level. Tumor dormancy and metastasis were also observed. Interestingly, in irradiated medaka, accelerated tumor growth and metastasis of the transplanted tumor cells were directly visualized. Our medaka model provides a new opportunity to visualize in vivo tumor cells"as seen in a culture dish", 第68回日本癌学会学術総会},
 title = {メダカモデル：生体内がん細胞動態の直接観察},
 year = {2009}
}