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マウス腫瘍の重粒子線照射効果関連遺伝子群の網羅的解析
https://repo.qst.go.jp/records/63613
https://repo.qst.go.jp/records/636137044d95f-26a5-437b-a5cd-51a986a65659
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-06 | |||||
| タイトル | ||||||
| タイトル | マウス腫瘍の重粒子線照射効果関連遺伝子群の網羅的解析 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
大久保, 悠
× 大久保, 悠× 岩川, 眞由美× 平川, 博一× 盛武, 敬× 酒井, 美奈子× 柳澤, 充× 中村, 悦子× 今井, 高志× 大久保 悠× 岩川 眞由美× 平川 博一× 盛武 敬× 酒井 美奈子× 柳澤 充× 中村 悦子× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To investigate the anti-metastatic efficacy of combination therapy of carbon-ion irradiation and NKT cell mediated-immunotherapy. \nMaterials and methods/Results: We inoculated mouse squamous cell carcinoma (NR-S1) cells into the leg of the mice, and irradiated with 15 Gy gamma-rays or 10 Gy of carbon-ions (290 MeV/n, 6cm SDBP). After 3.5 days from the irradiation, a-GalCer was locally injected into the primary tumor. In a group of mice irradiated with gamma-rays, the combination therapy reduced lung metastases, but was not statistically significant. On the other hand, carbon-ions suppressed lung metastasis strongly by itself, so additive effects of combination therapy was not observed. Then, we performed the experiments with less doses, such as 4 or 6 Gy of carbon-ions. We modified the immunotherapy as followings. GalCer pulsed dendritic cells (DCs) were administered as combined therapy. The combination of gamma-rays did not significantly decreased lung metastases, but in the 6 Gy carbon-ion irradiated groups, combination therapy reduced significantly lung metastases. \nConclusions: This study indicated the efficacy of combination therapy. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | H20年度HIMAC共同利用研究 成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-04-14 | |||||
| 日付タイプ | Issued | |||||
