@misc{oai:repo.qst.go.jp:00063613,
 author = {大久保, 悠 and 岩川, 眞由美 and 平川, 博一 and 盛武, 敬 and 酒井, 美奈子 and 柳澤, 充 and 中村, 悦子 and 今井, 高志 and 大久保 悠 and 岩川 眞由美 and 平川 博一 and 盛武 敬 and 酒井 美奈子 and 柳澤 充 and 中村 悦子 and 今井 高志},
 month = {Apr},
 note = {Purpose: To investigate the anti-metastatic efficacy of combination therapy of carbon-ion irradiation and NKT cell mediated-immunotherapy.
\nMaterials and methods/Results: We inoculated mouse squamous cell carcinoma (NR-S1) cells into the leg of the mice, and irradiated with 15 Gy gamma-rays or 10 Gy of carbon-ions (290 MeV/n, 6cm SDBP). After 3.5 days from the irradiation, a-GalCer was locally injected into the primary tumor. In a group of mice irradiated with gamma-rays, the combination therapy reduced lung metastases, but was not statistically significant. On the other hand, carbon-ions suppressed lung metastasis strongly by itself, so additive effects of combination therapy was not observed. Then, we performed the experiments with less doses, such as 4 or 6 Gy of carbon-ions. We modified the immunotherapy as followings. GalCer pulsed dendritic cells (DCs) were administered as combined therapy. The combination of gamma-rays did not significantly decreased lung metastases, but in the 6 Gy carbon-ion irradiated groups, combination therapy reduced significantly lung metastases. 
\nConclusions: This study indicated the efficacy of combination therapy., H20年度HIMAC共同利用研究 成果発表会},
 title = {マウス腫瘍の重粒子線照射効果関連遺伝子群の網羅的解析},
 year = {2009}
}