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Relationship between cell-killing and p53-dependent bystander effects in human cells induced by X-ray microplanar beams
https://repo.qst.go.jp/records/63600
https://repo.qst.go.jp/records/63600f501ef85-52fb-4ad9-82c8-176673d0a576
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-06 | |||||
| タイトル | ||||||
| タイトル | Relationship between cell-killing and p53-dependent bystander effects in human cells induced by X-ray microplanar beams | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Suzuki, Masao
× Suzuki, Masao× Kashino, Genro× Tsuruoka, Chizuru× Furusawa, Yoshiya× 鈴木 雅雄× 鶴岡 千鶴× 古澤 佳也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recent studies using X-ray microplanar beams generated with synchrotron radiation showed that radiobiological effects between normal and tumor tissue were quite different. This phenomenon has been attractive for a new technique of tumor radiotherapy, but it is still unknown not only biological effect itself but also its mechanism. This year we focused on the difference in the cell-killing effect between p53-wild and p53-mutated type human cell lines. Cells were irradiated with 25µm-thin (200µm beam space) X-ray microplanar beams generated with the SPring-8 at Japan Synchrotron Radiation Research Institute. The results showed that the recovery from the cell-killing effect was occurred in p53-wild type cells after 12h of post-irradiation incubation, but no recovery observed in p53-mutated type cells. Furthermore, the recovery was suppressed to the same level with the surviving fraction of the p53-mutated type cells, when using a specific inhibitor of gap-junction mediated cell-cell communications together. The results suggest that p53-mediated cellular responses play an important role of repair process between irradiated and non-irradiated cells with X-ray microplanar beams. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第68回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-10-03 | |||||
| 日付タイプ | Issued | |||||
