{"created":"2023-05-15T14:46:19.853121+00:00","id":63600,"links":{},"metadata":{"_buckets":{"deposit":"2c189dec-3f5a-4fdc-977d-d96296edc254"},"_deposit":{"created_by":1,"id":"63600","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63600"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063600","sets":["10:29"]},"author_link":["627684","627685","627688","627687","627683","627682","627686"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-10-03","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recent studies using X-ray microplanar beams generated with synchrotron radiation showed that radiobiological effects between normal and tumor tissue were quite different. This phenomenon has been attractive for a new technique of tumor radiotherapy, but it is still unknown not only biological effect itself but also its mechanism. This year we focused on the difference in the cell-killing effect between p53-wild and p53-mutated type human cell lines. Cells were irradiated with 25µm-thin (200µm beam space) X-ray microplanar beams generated with the SPring-8 at Japan Synchrotron Radiation Research Institute. The results showed that the recovery from the cell-killing effect was occurred in p53-wild type cells after 12h of post-irradiation incubation, but no recovery observed in p53-mutated type cells. Furthermore, the recovery was suppressed to the same level with the surviving fraction of the p53-mutated type cells, when using a specific inhibitor of gap-junction mediated cell-cell communications together. The results suggest that p53-mediated cellular responses play an important role of repair process between irradiated and non-irradiated cells with X-ray microplanar beams.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第68回日本癌学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Masao"}],"nameIdentifiers":[{"nameIdentifier":"627682","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kashino, Genro"}],"nameIdentifiers":[{"nameIdentifier":"627683","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuruoka, Chizuru"}],"nameIdentifiers":[{"nameIdentifier":"627684","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"627685","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 雅雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627686","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鶴岡 千鶴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627687","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627688","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Relationship between cell-killing and p53-dependent bystander effects in human cells induced by X-ray microplanar beams","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relationship between cell-killing and p53-dependent bystander effects in human cells induced by X-ray microplanar beams"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-06"},"publish_date":"2009-10-06","publish_status":"0","recid":"63600","relation_version_is_last":true,"title":["Relationship between cell-killing and p53-dependent bystander effects in human cells induced by X-ray microplanar beams"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:21:07.672821+00:00"}