@misc{oai:repo.qst.go.jp:00063600,
 author = {Suzuki, Masao and Kashino, Genro and Tsuruoka, Chizuru and Furusawa, Yoshiya and 鈴木 雅雄 and 鶴岡 千鶴 and 古澤 佳也},
 month = {Oct},
 note = {Recent studies using X-ray microplanar beams generated with synchrotron radiation showed that radiobiological effects between normal and tumor tissue were quite different. This phenomenon has been attractive for a new technique of tumor radiotherapy, but it is still unknown not only biological effect itself but also its mechanism. This year we focused on the difference in the cell-killing effect between p53-wild and p53-mutated type human cell lines. Cells were irradiated with 25µm-thin (200µm beam space) X-ray microplanar beams generated with the SPring-8 at Japan Synchrotron Radiation Research Institute. The results showed that the recovery from the cell-killing effect was occurred in p53-wild type cells after 12h of post-irradiation incubation, but no recovery observed in p53-mutated type cells. Furthermore, the recovery was suppressed to the same level with the surviving fraction of the p53-mutated type cells, when using a specific inhibitor of gap-junction mediated cell-cell communications together. The results suggest that p53-mediated cellular responses play an important role of repair process between irradiated and non-irradiated cells with X-ray microplanar beams., 第68回日本癌学会学術総会},
 title = {Relationship between cell-killing and p53-dependent bystander effects in human cells induced by X-ray microplanar beams},
 year = {2009}
}