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Investigation of atomoxetine occupancy of serotonin transporters using [11C]AFM
https://repo.qst.go.jp/records/63588
https://repo.qst.go.jp/records/63588cfc8fb79-7b4c-41f6-a1c5-18693ecff663
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-05 | |||||
| タイトル | ||||||
| タイトル | Investigation of atomoxetine occupancy of serotonin transporters using [11C]AFM | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
長縄, 美香
× 長縄, 美香× Ｇａｌｌｅｚｏｔ, Ｊｅａｎ−Ｄｏｍｉｎｉｑｕｅ× Ｈｕａｎｇ, Ｙｉｙｕｎ× Ｃａｒｓｏｎ, Ｒｉｃｈａｒｄ Ｅ．× Ｄｉｎｇ, Ｙｕ−Ｓｈｉｎ× その他× 長縄 美香 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: This study aimed at determining if a putative selective norepinephrine transporter (ATX), at clinically relevant doses, occupied SERT in a dose-dependent fashion in rhesus monkeys. Methods: Rhesus monkeys were scanned with [11C]AFM, a highly selective radioligand for SERT, (baseline & medium dose of ATX on day 1; low & high doses of ATX on day 2). Distribution volumes (VT) were estimated using MA1 and ATX IC50 values were calculated with measured ATX plasma levels and arterial input functions. Results: After administration of ATX, a dose-dependent occupancy from 46 to 92% was observed. VT in the cerebellum was reduced by up to around 30% with increasing ATX dose. The IC50 was estimated to be 122 +/- 11 ng/mL of plasma ATX concentration. Conclusions: This study demonstrated that ATX inhibited [11C]AFM binding in rhesus monkey brain in a dose-dependent fashion. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第49回日本核医学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2009-10-03 | |||||
| 日付タイプ | Issued | |||||
