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Investigation of atomoxetine occupancy of serotonin transporters using [11C]AFM
https://repo.qst.go.jp/records/63588
https://repo.qst.go.jp/records/63588cfc8fb79-7b4c-41f6-a1c5-18693ecff663
Item type | 会議発表用資料 / Presentation(1) | |||||
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公開日 | 2009-10-05 | |||||
タイトル | ||||||
タイトル | Investigation of atomoxetine occupancy of serotonin transporters using [11C]AFM | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
資源タイプ | conference object | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
長縄, 美香
× 長縄, 美香× Gallezot, Jean−Dominique× Huang, Yiyun× Carson, Richard E.× Ding, Yu−Shin× その他× 長縄 美香 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objectives: This study aimed at determining if a putative selective norepinephrine transporter (ATX), at clinically relevant doses, occupied SERT in a dose-dependent fashion in rhesus monkeys. Methods: Rhesus monkeys were scanned with [11C]AFM, a highly selective radioligand for SERT, (baseline & medium dose of ATX on day 1; low & high doses of ATX on day 2). Distribution volumes (VT) were estimated using MA1 and ATX IC50 values were calculated with measured ATX plasma levels and arterial input functions. Results: After administration of ATX, a dose-dependent occupancy from 46 to 92% was observed. VT in the cerebellum was reduced by up to around 30% with increasing ATX dose. The IC50 was estimated to be 122 +/- 11 ng/mL of plasma ATX concentration. Conclusions: This study demonstrated that ATX inhibited [11C]AFM binding in rhesus monkey brain in a dose-dependent fashion. |
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会議概要(会議名, 開催地, 会期, 主催者等) | ||||||
内容記述タイプ | Other | |||||
内容記述 | 第49回日本核医学会学術総会 | |||||
発表年月日 | ||||||
日付 | 2009-10-03 | |||||
日付タイプ | Issued |