{"created":"2023-05-15T14:46:19.315259+00:00","id":63588,"links":{},"metadata":{"_buckets":{"deposit":"e20b5ff0-e960-4afa-8727-591c4cbe9f33"},"_deposit":{"created_by":1,"id":"63588","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63588"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063588","sets":["10:29"]},"author_link":["627585","627582","627584","627587","627581","627586","627583"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2009-10-03","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: This study aimed at determining if a putative selective norepinephrine transporter (ATX), at clinically relevant doses, occupied SERT in a dose-dependent fashion in rhesus monkeys. \nMethods: Rhesus monkeys were scanned with [11C]AFM, a highly selective radioligand for SERT, (baseline & medium dose of ATX on day 1; low & high doses of ATX on day 2). Distribution volumes (VT) were estimated using MA1 and ATX IC50 values were calculated with measured ATX plasma levels and arterial input functions.\nResults: After administration of ATX, a dose-dependent occupancy from 46 to 92% was observed. VT in the cerebellum was reduced by up to around 30% with increasing ATX dose. The IC50 was estimated to be 122 +/- 11 ng/mL of plasma ATX concentration.\nConclusions: This study demonstrated that ATX inhibited [11C]AFM binding in rhesus monkey brain in a dose-dependent fashion.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第49回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長縄, 美香"}],"nameIdentifiers":[{"nameIdentifier":"627581","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｇａｌｌｅｚｏｔ, Ｊｅａｎ−Ｄｏｍｉｎｉｑｕｅ"}],"nameIdentifiers":[{"nameIdentifier":"627582","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｈｕａｎｇ, Ｙｉｙｕｎ"}],"nameIdentifiers":[{"nameIdentifier":"627583","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｃａｒｓｏｎ, Ｒｉｃｈａｒｄ Ｅ．"}],"nameIdentifiers":[{"nameIdentifier":"627584","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｄｉｎｇ, Ｙｕ−Ｓｈｉｎ"}],"nameIdentifiers":[{"nameIdentifier":"627585","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"627586","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長縄 美香","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627587","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Investigation of atomoxetine occupancy of serotonin transporters using [11C]AFM","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Investigation of atomoxetine occupancy of serotonin transporters using [11C]AFM"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-05"},"publish_date":"2009-10-05","publish_status":"0","recid":"63588","relation_version_is_last":true,"title":["Investigation of atomoxetine occupancy of serotonin transporters using [11C]AFM"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:21:15.955270+00:00"}