@misc{oai:repo.qst.go.jp:00063588,
 author = {長縄, 美香 and Ｇａｌｌｅｚｏｔ, Ｊｅａｎ−Ｄｏｍｉｎｉｑｕｅ and Ｈｕａｎｇ, Ｙｉｙｕｎ and Ｃａｒｓｏｎ, Ｒｉｃｈａｒｄ Ｅ． and Ｄｉｎｇ, Ｙｕ−Ｓｈｉｎ and その他 and 長縄 美香},
 month = {Oct},
 note = {Objectives: This study aimed at determining if a putative selective norepinephrine transporter (ATX), at clinically relevant doses, occupied SERT in a dose-dependent fashion in rhesus monkeys. 
Methods: Rhesus monkeys were scanned with [11C]AFM, a highly selective radioligand for SERT, (baseline & medium dose of ATX on day 1; low & high doses of ATX on day 2). Distribution volumes (VT) were estimated using MA1 and ATX IC50 values were calculated with measured ATX plasma levels and arterial input functions.
Results: After administration of ATX, a dose-dependent occupancy from 46 to 92% was observed. VT in the cerebellum was reduced by up to around 30% with increasing ATX dose. The IC50 was estimated to be 122 +/- 11 ng/mL of plasma ATX concentration.
Conclusions: This study demonstrated that ATX inhibited [11C]AFM binding in rhesus monkey brain in a dose-dependent fashion., 第49回日本核医学会学術総会},
 title = {Investigation of atomoxetine occupancy of serotonin transporters using [11C]AFM},
 year = {2009}
}