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ヒト巨核球・血小板造血過程における遺伝子発現の変化と放射線の影響
https://repo.qst.go.jp/records/63577
https://repo.qst.go.jp/records/63577947975d0-0f6a-4917-a4fd-410884f2e3b4
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-10-01 | |||||
| タイトル | ||||||
| タイトル | ヒト巨核球・血小板造血過程における遺伝子発現の変化と放射線の影響 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
柏倉, 幾郎
× 柏倉, 幾郎× 高橋, 賢次× 門前, 暁× 吉野, 浩教× 阿部, 由直× 江口−笠井, 清美× 柏倉 幾郎× 高橋 賢次× 門前 暁× 吉野 浩教× 阿部 由直× 笠井 清美 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To demonstrate the effects of high and low LET-radiation on human megakaryocyte development and platelet production, the gene expressions of hematopoietic stem/progenitor cells exposed to heavy ion beams and X-rays were analyzed. CD34+ cells derived from placental and umbilical cord blood were induced by carbon-ion beams (LET = 50 keV) or X-rays at 2 Gy, differentiated into megakaryocytes and platelets with thrombopoietin (TPO) and interleukin-3 (IL-3) for 7 days and then assayed using real time RT-PCR. FLI1 and RUNX1, positive regulators of megakaryocytopoiesis, were up-regulated by the exposure to carbon-ion beams. The expressions of MPL, ITGA2B and GPIBA, the megakaryocyte-specific genes, were reduced by X-irradiation. In other factors, X-rays increased the expression of KIT, the receptor for SCF while carbon-ion beams enhanced the expression of C/EBPA, a myeloid transcription factor. These results showed that the regulation of several gene expressions were dependent on each radiation, respectively. The relations of these molecules on human megakaryocytopoiesis and thrombopoiesis remain to be examined. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成19年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究成果発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-04-15 | |||||
| 日付タイプ | Issued | |||||
