{"created":"2023-05-15T14:46:18.828265+00:00","id":63577,"links":{},"metadata":{"_buckets":{"deposit":"eccc0bf8-fd1a-431a-a7f3-5c83536340fe"},"_deposit":{"created_by":1,"id":"63577","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"63577"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00063577","sets":["10:29"]},"author_link":["627485","627483","627481","627486","627480","627477","627487","627488","627482","627478","627479","627484"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-04-15","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To demonstrate the effects of high and low\nLET-radiation on human megakaryocyte\ndevelopment and platelet production, the gene\nexpressions of hematopoietic stem/progenitor cells\nexposed to heavy ion beams and X-rays were\nanalyzed.\nCD34+ cells derived from placental and umbilical\ncord blood were induced by carbon-ion beams\n(LET = 50 keV) or X-rays at 2 Gy, differentiated\ninto megakaryocytes and platelets with\nthrombopoietin (TPO) and interleukin-3 (IL-3) for\n7 days and then assayed using real time RT-PCR.\nFLI1 and RUNX1, positive regulators of\nmegakaryocytopoiesis, were up-regulated by the\nexposure to carbon-ion beams. The expressions of\nMPL, ITGA2B and GPIBA, the\nmegakaryocyte-specific genes, were reduced by\nX-irradiation. In other factors, X-rays increased the\nexpression of KIT, the receptor for SCF while\ncarbon-ion beams enhanced the expression of\nC/EBPA, a myeloid transcription factor.\nThese results showed that the regulation of several\ngene expressions were dependent on each radiation,\nrespectively. The relations of these molecules on\nhuman megakaryocytopoiesis and thrombopoiesis\nremain to be examined.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"平成19年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究成果発表会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"柏倉, 幾郎"}],"nameIdentifiers":[{"nameIdentifier":"627477","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋, 賢次"}],"nameIdentifiers":[{"nameIdentifier":"627478","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"門前, 暁"}],"nameIdentifiers":[{"nameIdentifier":"627479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉野, 浩教"}],"nameIdentifiers":[{"nameIdentifier":"627480","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阿部, 由直"}],"nameIdentifiers":[{"nameIdentifier":"627481","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江口−笠井, 清美"}],"nameIdentifiers":[{"nameIdentifier":"627482","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柏倉 幾郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627483","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 賢次","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627484","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"門前 暁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627485","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉野 浩教","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627486","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阿部 由直","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627487","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笠井 清美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"627488","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ヒト巨核球・血小板造血過程における遺伝子発現の変化と放射線の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト巨核球・血小板造血過程における遺伝子発現の変化と放射線の影響"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-10-01"},"publish_date":"2009-10-01","publish_status":"0","recid":"63577","relation_version_is_last":true,"title":["ヒト巨核球・血小板造血過程における遺伝子発現の変化と放射線の影響"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:21:23.687058+00:00"}