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子宮頚癌放射線治療の副作用発症リスクと関連するハプロタイプの同定
https://repo.qst.go.jp/records/62836
https://repo.qst.go.jp/records/62836af1b19e4-faca-4ec9-a85d-6f73565314a1
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-30 | |||||
| タイトル | ||||||
| タイトル | 子宮頚癌放射線治療の副作用発症リスクと関連するハプロタイプの同定 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
石川, 敦子
× 石川, 敦子× 岩川, 眞由美× 大野, 達也× 加藤, 真吾× 芝本, 雄太× 辻井, 博彦× 今井, 高志× 石川 敦子× 岩川 眞由美× 大野 達也× 加藤 眞吾× 芝本 雄太× 辻井 博彦× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To identify haplotypes of SNP markers associated with risk of adverse reactions after radiotherapy (RT). Patients and Methods: DNA samples were collected from 153 cervical cancer patients, who underwent conventional RT. The ninety-two patients received no chemotherapy. A total of 1201 SNPs from 173 candidate genes for radiation susceptibility were genotyped, and haplotype associations between groups were assessed. Results: Using the NCI-CTC scoring system, the patients were grouped according to adverse gastrointestinal reaction within 3 months of starting radiotherapy: a reaction grade =< 1, n = 106, and the reaction grade >= 2, n = 47. No association between any clinical factors and the adverse reactions was observed. Global haplotype association analysis (P < 0.05 and false discovery rate < 0.05) indicated that estimated haplotypes in the 8 loci were associated with risk. We revealed 4 haplotypes significantly related with adverse reaction risks. Conclusions: Individual radiosensitivity may be partly determined by these haplotypes in multiple loci. Our data could be the evidence to lead a better understanding of the mechanisms in individual radiation sensitivity. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第67回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-10-30 | |||||
| 日付タイプ | Issued | |||||
