@misc{oai:repo.qst.go.jp:00062836,
 author = {石川, 敦子 and 岩川, 眞由美 and 大野, 達也 and 加藤, 真吾 and 芝本, 雄太 and 辻井, 博彦 and 今井, 高志 and 石川 敦子 and 岩川 眞由美 and 大野 達也 and 加藤 眞吾 and 芝本 雄太 and 辻井 博彦 and 今井 高志},
 month = {Oct},
 note = {Purpose: To identify haplotypes of SNP markers associated with risk of adverse reactions after radiotherapy (RT).
Patients and Methods: DNA samples were collected from 153 cervical cancer patients, who underwent conventional RT. The ninety-two patients received no chemotherapy. A total of 1201 SNPs from 173 candidate genes for radiation susceptibility were genotyped, and haplotype associations between groups were assessed.
Results: Using the NCI-CTC scoring system, the patients were grouped according to adverse gastrointestinal reaction within 3 months of starting radiotherapy: a reaction grade =< 1, n = 106, and the reaction grade >= 2, n = 47. No association between any clinical factors and the adverse reactions was observed. Global haplotype association analysis (P < 0.05 and false discovery rate < 0.05) indicated that estimated haplotypes in the 8 loci were associated with risk. We revealed 4 haplotypes significantly related with adverse reaction risks. 
Conclusions: Individual radiosensitivity may be partly determined by these haplotypes in multiple loci. Our data could be the evidence to lead a better understanding of the mechanisms in individual radiation sensitivity., 第67回日本癌学会学術総会},
 title = {子宮頚癌放射線治療の副作用発症リスクと関連するハプロタイプの同定},
 year = {2008}
}