{"created":"2023-05-15T14:45:59.874629+00:00","id":62836,"links":{},"metadata":{"_buckets":{"deposit":"c32308b3-a813-4449-bac5-948ac840b4b8"},"_deposit":{"created_by":1,"id":"62836","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62836"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062836","sets":["10:29"]},"author_link":["620701","620695","620693","620702","620698","620696","620691","620697","620692","620694","620700","620689","620690","620699"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008-10-30","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: To identify haplotypes of SNP markers associated with risk of adverse reactions after radiotherapy (RT).\nPatients and Methods: DNA samples were collected from 153 cervical cancer patients, who underwent conventional RT. The ninety-two patients received no chemotherapy. A total of 1201 SNPs from 173 candidate genes for radiation susceptibility were genotyped, and haplotype associations between groups were assessed.\nResults: Using the NCI-CTC scoring system, the patients were grouped according to adverse gastrointestinal reaction within 3 months of starting radiotherapy: a reaction grade =< 1, n = 106, and the reaction grade >= 2, n = 47. No association between any clinical factors and the adverse reactions was observed. Global haplotype association analysis (P < 0.05 and false discovery rate < 0.05) indicated that estimated haplotypes in the 8 loci were associated with risk. We revealed 4 haplotypes significantly related with adverse reaction risks. \nConclusions: Individual radiosensitivity may be partly determined by these haplotypes in multiple loci. Our data could be the evidence to lead a better understanding of the mechanisms in individual radiation sensitivity.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第67回日本癌学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石川, 敦子"}],"nameIdentifiers":[{"nameIdentifier":"620689","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川, 眞由美"}],"nameIdentifiers":[{"nameIdentifier":"620690","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大野, 達也"}],"nameIdentifiers":[{"nameIdentifier":"620691","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤, 真吾"}],"nameIdentifiers":[{"nameIdentifier":"620692","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"芝本, 雄太"}],"nameIdentifiers":[{"nameIdentifier":"620693","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井, 博彦"}],"nameIdentifiers":[{"nameIdentifier":"620694","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井, 高志"}],"nameIdentifiers":[{"nameIdentifier":"620695","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 敦子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620696","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620697","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大野 達也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620698","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"加藤 眞吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620699","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"芝本 雄太","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620700","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620701","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"620702","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"子宮頚癌放射線治療の副作用発症リスクと関連するハプロタイプの同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"子宮頚癌放射線治療の副作用発症リスクと関連するハプロタイプの同定"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-10-30"},"publish_date":"2008-10-30","publish_status":"0","recid":"62836","relation_version_is_last":true,"title":["子宮頚癌放射線治療の副作用発症リスクと関連するハプロタイプの同定"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:26:11.537818+00:00"}