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胎児・成体マウスにおける放射線誘発適応応答は重粒子線にも当て嵌まるか
https://repo.qst.go.jp/records/62766
https://repo.qst.go.jp/records/62766133890fc-4286-4623-a80d-f8f908590e5f
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-10-08 | |||||
| タイトル | ||||||
| タイトル | 胎児・成体マウスにおける放射線誘発適応応答は重粒子線にも当て嵌まるか | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
王, 冰
× 王, 冰× 田中, 薫× Ｇｕｉｌｌａｕｍｅ, Ｖａｒｅｓ× 尚, 奕× 二宮, 康晴× 藤田, 和子× 笠井, 清美× 根井, 充× 王 冰× 田中 薫× Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ× 尚 奕× 二宮 康晴× 藤田 和子× 笠井 清美× 根井 充 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Possible induction of adaptive response by high LET irradiation of accelerated heavy ions is to be tested both in vivo in young adult mice and in utero in fetal mice of C57BL strain. Investigations are to verify 1) if the known X-ray-induced adaptive response could reduce any heavy-ion-induced detrimental effects such as death or malformation, 2) if the heavy ion irradiation at certain low dose could induce any adaptive response against the detrimental effects induced by high dose of X-irradiations, and 3) if the heavy-ion irradiation at certain low dose could induce any adaptive response against the detrimental effects induced by high dose of heavy ion irradiations. Three kinds of accelerated heavy ions are to be examined, 1) carbon (290MeV/u) mono beams with a linear energy transfer (LET) value of about 15 keV/mm, silicon (490MeV/u) mono beams with a LET value of about 55 keV/mm and ion (500MeV/u) mono beams with a LET value of about 200 keV/mm. At the beginning of this work in the latter half of the fiscal year 2007, we searched for the suitable challenging dose for either the fetal mice or the adult mice. In the first half of the fiscal year 2008, it will be the tasks to test if the priming low dose X-irradiations could induce any protective effect against the detrimental effects from the high LET heavy-ion challenging irradiations. In the latter half of the fiscal year 2008, we will try to check if the priming heavy-ion irradiations at certain low doses could induce any protective effect against the detrimental effects from the high dose challenging X-irradiations. In the fiscal year 2009, both priming and challenging doses will be performed using heavy-ion irradiations, and we would expect an answer to the raised question "Does Radioadaptive Response Also Apply to the Case of Heavy-ion Irradiations in Fetal and Adult Mice?" and find some evidential clue to the mechanisms underlying these phenomena. The work on searching for the suitable challenging dose for the in utero experiment is finished while the work is undergoing for the in vivo experiment. Here the obtained data so far are presented in this annual research report meeting. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 平成19年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究発表会 | |||||
| 発表年月日 | ||||||
| 日付 | 2008-04-15 | |||||
| 日付タイプ | Issued | |||||
