@misc{oai:repo.qst.go.jp:00062766,
 author = {王, 冰 and 田中, 薫 and Ｇｕｉｌｌａｕｍｅ, Ｖａｒｅｓ and 尚, 奕 and 二宮, 康晴 and 藤田, 和子 and 笠井, 清美 and 根井, 充 and 王 冰 and 田中 薫 and Ｇｕｉｌｌａｕｍｅ Ｖａｒｅｓ and 尚 奕 and 二宮 康晴 and 藤田 和子 and 笠井 清美 and 根井 充},
 month = {Apr},
 note = {Possible induction of adaptive response by high LET irradiation of
accelerated heavy ions is to be tested both in vivo in young adult mice and
in utero in fetal mice of C57BL strain. Investigations are to verify 1) if
the known X-ray-induced adaptive response could reduce any heavy-ion-induced
detrimental effects such as death or malformation, 2) if the heavy ion
irradiation at certain low dose could induce any adaptive response against
the detrimental effects induced by high dose of X-irradiations, and 3) if
the heavy-ion irradiation at certain low dose could induce any adaptive
response against the detrimental effects induced by high dose of heavy ion
irradiations. Three kinds of accelerated heavy ions are to be examined, 1)
carbon (290MeV/u) mono beams with a linear energy transfer (LET) value of
about 15 keV/mm, silicon (490MeV/u) mono beams with a LET value of about 55
keV/mm and ion (500MeV/u) mono beams with a LET value of about 200 keV/mm.
At the beginning of this work in the latter half of the fiscal year 2007, we
searched for the suitable challenging dose for either the fetal mice or the
adult mice. In the first half of the fiscal year 2008, it will be the tasks
to test if the priming low dose X-irradiations could induce any protective
effect against the detrimental effects from the high LET heavy-ion
challenging irradiations. In the latter half of the fiscal year 2008, we
will try to check if the priming heavy-ion irradiations at certain low doses
could induce any protective effect against the detrimental effects from the
high dose challenging X-irradiations. In the fiscal year 2009, both priming
and challenging doses will be performed using heavy-ion irradiations, and we
would expect an answer to the raised question "Does Radioadaptive Response
Also Apply to the Case of Heavy-ion Irradiations in Fetal and Adult Mice?"
and find some evidential clue to the mechanisms underlying these phenomena.
The work on searching for the suitable challenging dose for the in utero
experiment is finished while the work is undergoing for the in vivo
experiment. Here the obtained data so far are presented in this annual
research report meeting., 平成19年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究発表会},
 title = {胎児・成体マウスにおける放射線誘発適応応答は重粒子線にも当て嵌まるか},
 year = {2008}
}