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Prolongation of Life Span of Disease Model Mice by Low Dose Rate Irradiation
https://repo.qst.go.jp/records/61711
https://repo.qst.go.jp/records/61711069d06cb-1a31-4792-a950-ab717bf72119
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-08-07 | |||||
| タイトル | ||||||
| タイトル | Prolongation of Life Span of Disease Model Mice by Low Dose Rate Irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sakai, Kazuo
× Sakai, Kazuo× 酒井 一夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Prolongation of Life Span of Disease Model Mice by Low Dose Rate Irradiation \nKazuo Sakai, Low Dose Radiation Research Center, Central Research Institute of Electric Power Industry. 2-11-1 Iwado-kita, Komae, Tokyo 201-8511, Japan, Telephone: +81 3 3480 2111, Fax: +81 3 3480 3113, Email: kazsakai@criepi.denken.or.jp \nWe examined the effects of low dose rate gamma irradiation on physical status and life span in disease model mice. In Type II diabetic C57BL/KsJ-db/db mice, the urine glucose level was improved in some of the mice irradiated at 0.70 mGy/hr but not in the non-irradiated control mice. Mortality was delayed and a healthy appearance was prolonged in the irradiated mice by about 20-30 weeks compared with the control mice; The last mouse in the non-irradiated control group died at the 121st week, and the one in the irradiated group, at the 147th week. In severe autoimmune MRL-lpr/lpr mice, the immunological status was kept better and the incidence of a number of symptoms, including lymphadenopathy, splenomegaly and proteinuria, was suppressed in the mice irradiated at 0.35 or 1.2 mGy/hr. The life span was prolonged in the irradiated mice. Four-week-old female klotho mice (kl/kl), a premature-aging syndrome model, were irradiated with gamma rays at 0.35, 0.70 or 1.2 mGy/hr. All of the 20 non-irradiated mice died by 65th day of age; while the last mouse in the group irradiated at 0.7 mGy/hr died on 120th day of age. The irradiation at 0.35 mGy/hr was less effective, and no life span prolongation was observed in the mice irradiated at 1.2 mGy/hr. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | The 5th International Conference on Hormesis | |||||
| 発表年月日 | ||||||
| 日付 | 2006-06-08 | |||||
| 日付タイプ | Issued | |||||
