@misc{oai:repo.qst.go.jp:00061711,
 author = {Sakai, Kazuo and 酒井 一夫},
 month = {Jun},
 note = {Prolongation of Life Span of Disease Model Mice by Low Dose Rate Irradiation 
\nKazuo Sakai, Low Dose Radiation Research Center, Central Research Institute of Electric Power Industry. 2-11-1 Iwado-kita, Komae, Tokyo 201-8511, Japan, Telephone: +81 3 3480 2111, Fax: +81 3 3480 3113, Email: kazsakai@criepi.denken.or.jp
\nWe examined the effects of low dose rate gamma irradiation on physical status and life span in disease model mice.  In Type II diabetic C57BL/KsJ-db/db mice, the urine glucose level was improved in some of the mice irradiated at 0.70 mGy/hr but not in the non-irradiated control mice. Mortality was delayed and a healthy appearance was prolonged in the irradiated mice by about 20-30 weeks compared with the control mice; The last mouse in the non-irradiated control group died at the 121st week, and the one in the irradiated group, at the 147th week. In severe autoimmune MRL-lpr/lpr mice, the immunological status was kept better and the incidence of a number of symptoms, including lymphadenopathy, splenomegaly and proteinuria, was suppressed in the mice irradiated at 0.35 or 1.2 mGy/hr. The life span was prolonged in the irradiated mice. Four-week-old female klotho mice (kl/kl), a premature-aging syndrome model, were irradiated with gamma rays at 0.35, 0.70 or 1.2 mGy/hr. All of the 20 non-irradiated mice died by 65th day of age; while the last mouse in the group irradiated at 0.7 mGy/hr died on 120th day of age.  The irradiation at 0.35 mGy/hr was less effective, and no life span prolongation was observed in the mice irradiated at 1.2 mGy/hr., The 5th International Conference on Hormesis},
 title = {Prolongation of Life Span of Disease Model Mice by Low Dose Rate Irradiation},
 year = {2006}
}