{"created":"2023-05-15T14:45:09.500593+00:00","id":61711,"links":{},"metadata":{"_buckets":{"deposit":"205df916-7bac-4590-8d3f-65cd27629e1b"},"_deposit":{"created_by":1,"id":"61711","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"61711"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00061711","sets":["10:29"]},"author_link":["610940","610939"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2006-06-08","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Prolongation of Life Span of Disease Model Mice by Low Dose Rate Irradiation \n\\nKazuo Sakai, Low Dose Radiation Research Center, Central Research Institute of Electric Power Industry. 2-11-1 Iwado-kita, Komae, Tokyo 201-8511, Japan, Telephone: +81 3 3480 2111, Fax: +81 3 3480 3113, Email: kazsakai@criepi.denken.or.jp\n\\nWe examined the effects of low dose rate gamma irradiation on physical status and life span in disease model mice.  In Type II diabetic C57BL/KsJ-db/db mice, the urine glucose level was improved in some of the mice irradiated at 0.70 mGy/hr but not in the non-irradiated control mice. Mortality was delayed and a healthy appearance was prolonged in the irradiated mice by about 20-30 weeks compared with the control mice; The last mouse in the non-irradiated control group died at the 121st week, and the one in the irradiated group, at the 147th week. In severe autoimmune MRL-lpr/lpr mice, the immunological status was kept better and the incidence of a number of symptoms, including lymphadenopathy, splenomegaly and proteinuria, was suppressed in the mice irradiated at 0.35 or 1.2 mGy/hr. The life span was prolonged in the irradiated mice. Four-week-old female klotho mice (kl/kl), a premature-aging syndrome model, were irradiated with gamma rays at 0.35, 0.70 or 1.2 mGy/hr. All of the 20 non-irradiated mice died by 65th day of age; while the last mouse in the group irradiated at 0.7 mGy/hr died on 120th day of age.  The irradiation at 0.35 mGy/hr was less effective, and no life span prolongation was observed in the mice irradiated at 1.2 mGy/hr.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The 5th International Conference on Hormesis","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakai, Kazuo"}],"nameIdentifiers":[{"nameIdentifier":"610939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"酒井 一夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"610940","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Prolongation of Life Span of Disease Model Mice by Low Dose Rate Irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prolongation of Life Span of Disease Model Mice by Low Dose Rate Irradiation"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-08-07"},"publish_date":"2006-08-07","publish_status":"0","recid":"61711","relation_version_is_last":true,"title":["Prolongation of Life Span of Disease Model Mice by Low Dose Rate Irradiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:39:11.829548+00:00"}