WEKO3
アイテム
Improvement of 62Zn/62Cu generator based on cation exchange methods and its quality control.
https://repo.qst.go.jp/records/61492
https://repo.qst.go.jp/records/61492236ff9ed-a203-43ce-a515-5d2e506c3eab
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-15 | |||||
| タイトル | ||||||
| タイトル | Improvement of 62Zn/62Cu generator based on cation exchange methods and its quality control. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fukumura, Toshimitsu
× Fukumura, Toshimitsu× Okada, Kazuhiro× Nakao, Ryuji× Suzuki, Hisashi× Mukai, Kensaku× Ferenc, Szelecsenyi× Kovacs, Zoltan× Suzuki, Kazutoshi× 福村 利光× 中尾 隆士× 鈴木 寿× 向井 健作× Ｆｅｒｅｎｃ Ｓｚｅｌｅｃｓｅｎｙｉ× ゾルタン コバックス× 鈴木 和年 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The generator nuclide 62Cu (T1/2 = 9.7 min) is a suitable positron emitter for repeated PET study without a cyclotron. A 62Zn/62Cu generator, which employs an anion exchange resin as a generator column [1], has been widely used as a 62Cu source for the synthesis of useful 62Cu-labeled radiopharmaceuticals, such as 62Cu-PTSM [2, 3]. However, this generator had some disadvantages such as high osmotic pressure, low pH and low elution efficiency. Another type of 62Zn/62Cu generator, which uses a strong cation exchange resin as a generator column and glycine (Gly) solution for the elution of 62Cu, has been developed by Fujibayashi et al. [4]. This generator yields 62Cu solutions with high elution efficiency under physiological conditions. However, the 62Cu solution was contaminated by relatively large amount of 62Zn (~2.2%). We found that the 62Cu elution efficiency and 62Zn leakage level were highly improved using the Sep Pak CM cartridge, which is a silica based weak anion exchanger. Therefore, we applied this cartridge to the 62Zn/62Cu generator to establish a generator column. We report here the improved 62Zn/62Cu generator and its performance. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 16th International Symposium on Radiopharmaceutical Chemistry | |||||
| 発表年月日 | ||||||
| 日付 | 2005-06-28 | |||||
| 日付タイプ | Issued | |||||
