@misc{oai:repo.qst.go.jp:00061492,
 author = {Fukumura, Toshimitsu and Okada, Kazuhiro and Nakao, Ryuji and Suzuki, Hisashi and Mukai, Kensaku and Ferenc, Szelecsenyi and Kovacs, Zoltan and Suzuki, Kazutoshi and 福村 利光 and 中尾 隆士 and 鈴木 寿 and 向井 健作 and Ｆｅｒｅｎｃ Ｓｚｅｌｅｃｓｅｎｙｉ and ゾルタン コバックス and 鈴木 和年},
 month = {Jun},
 note = {The generator nuclide 62Cu (T1/2 = 9.7 min) is a suitable positron emitter for repeated PET study without a cyclotron. A 62Zn/62Cu generator, which employs an anion exchange resin as a generator column [1], has been widely used as a 62Cu source for the synthesis of useful 62Cu-labeled radiopharmaceuticals, such as 62Cu-PTSM [2, 3]. However, this generator had some disadvantages such as high osmotic pressure, low pH and low elution efficiency. Another type of 62Zn/62Cu generator, which uses a strong cation exchange resin as a generator column and glycine (Gly) solution for the elution of 62Cu, has been developed by Fujibayashi et al. [4]. This generator yields 62Cu solutions with high elution efficiency under physiological conditions. However, the 62Cu solution was contaminated by relatively large amount of 62Zn (~2.2%).  We found that the 62Cu elution efficiency and 62Zn leakage level were highly improved using the Sep Pak CM cartridge, which is a silica based weak anion exchanger.  Therefore, we applied this cartridge to the 62Zn/62Cu generator to establish a generator column. We report here the improved 62Zn/62Cu generator and its performance., 16th　International Symposium on Radiopharmaceutical Chemistry},
 title = {Improvement of 62Zn/62Cu generator based on cation exchange methods and its quality control.},
 year = {2005}
}