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LET Dependent Recovery of Mouse Hematopoietic Stem Cells from Particle Irradiation
https://repo.qst.go.jp/records/59921
https://repo.qst.go.jp/records/59921607fbd7e-e249-495c-acd5-2a857d68ed73
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-08-27 | |||||
| タイトル | ||||||
| タイトル | LET Dependent Recovery of Mouse Hematopoietic Stem Cells from Particle Irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nojima, Kumie
× Nojima, Kumie× Nagaoka, Shunji× 野島 久美恵× 長岡 俊治 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation induced acute changes of mouse heamatopoietic functions and its recovery were studied in different LET of heavy ions, carbon (13keV/mm and 30 keV/mm), neon (32 keV/mm and 55 keV/mm), silicon (56 keV/mm), argon (85 keV/mm) iron (200 keV/mm). After whole body irradiation was applied up to 3 Gy, the subsequent heamatopoietic parameters were followed by the blood analysis for 3 weeks, All functions, spleen weight, WBC, hemoglobin concentration, granulocyte-monocyte colony forming unit (GM-CFU) in bone marrow and spleen indicated dose dependent reduction within 2 days after the irradiation and followed by a slow recovery. Complete recovery took approximately 3 weeks for all functions. GM-CFU in spleen showed the highest sensitivity to all particles indicating a large reduction down to less than 1 % of control at 3 Gy exposured. Of the particle exposed Si (55 keV/mm) induced the largest effects and the slowest recovery, whereas Fe (200 keV/mm) indicated signidicantly the lsast effects and quick recovery. The results suggested a strong LET dependency of the heamatopoietic progenitor cells which may have a RBE maximun less than 100 keV/mm. The recovery kinetics inducated non-monotonic increase within 10 days suggested an involvement of time dependent releases of cytokines (IL-1b ___ IL-3) which may modify the proliferation of hematopoietic cells. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 12th International Congress of Radiation Research | |||||
| 発表年月日 | ||||||
| 日付 | 2003-08-22 | |||||
| 日付タイプ | Issued | |||||
