{"created":"2023-05-15T14:43:48.089592+00:00","id":59921,"links":{},"metadata":{"_buckets":{"deposit":"879950c1-4c3e-4473-b8d8-052f123609db"},"_deposit":{"created_by":1,"id":"59921","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"59921"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00059921","sets":["10:29"]},"author_link":["596036","596038","596037","596039"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2003-08-22","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Radiation induced acute changes of mouse heamatopoietic functions and its recovery were studied in different LET of heavy ions, carbon (13keV/mm and 30 keV/mm), neon (32 keV/mm and 55 keV/mm), silicon (56 keV/mm), argon (85 keV/mm) iron (200 keV/mm). After whole body irradiation was applied up to 3 Gy, the subsequent heamatopoietic parameters were followed by the blood analysis for 3 weeks, All functions, spleen weight, WBC, hemoglobin concentration, granulocyte-monocyte colony forming unit (GM-CFU) in bone marrow and spleen indicated dose dependent reduction within 2 days after the irradiation and followed by a slow recovery. Complete recovery took approximately 3 weeks for all functions. GM-CFU in spleen showed the highest sensitivity to all particles indicating a large reduction down to less than 1 % of control at 3 Gy exposured. Of the particle exposed Si (55 keV/mm) induced the largest effects and the slowest recovery, whereas Fe (200 keV/mm) indicated signidicantly the lsast effects and quick recovery. The results suggested a strong LET dependency of the heamatopoietic progenitor cells which may have a RBE maximun less than 100 keV/mm. The recovery kinetics inducated non-monotonic increase within 10 days suggested an involvement of time dependent releases of cytokines (IL-1b ___ IL-3) which may modify the proliferation of hematopoietic cells.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"12th International Congress of Radiation Research","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nojima, Kumie"}],"nameIdentifiers":[{"nameIdentifier":"596036","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagaoka, Shunji"}],"nameIdentifiers":[{"nameIdentifier":"596037","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野島 久美恵","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"596038","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長岡 俊治","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"596039","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"LET Dependent Recovery of Mouse Hematopoietic Stem Cells from Particle Irradiation ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"LET Dependent Recovery of Mouse Hematopoietic Stem Cells from Particle Irradiation "}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-08-27"},"publish_date":"2003-08-27","publish_status":"0","recid":"59921","relation_version_is_last":true,"title":["LET Dependent Recovery of Mouse Hematopoietic Stem Cells from Particle Irradiation "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:59:32.594000+00:00"}