@misc{oai:repo.qst.go.jp:00059921,
 author = {Nojima, Kumie and Nagaoka, Shunji and 野島 久美恵 and 長岡 俊治},
 month = {Aug},
 note = {Radiation induced acute changes of mouse heamatopoietic functions and its recovery were studied in different LET of heavy ions, carbon (13keV/mm and 30 keV/mm), neon (32 keV/mm and 55 keV/mm), silicon (56 keV/mm), argon (85 keV/mm) iron (200 keV/mm). After whole body irradiation was applied up to 3 Gy, the subsequent heamatopoietic parameters were followed by the blood analysis for 3 weeks, All functions, spleen weight, WBC, hemoglobin concentration, granulocyte-monocyte colony forming unit (GM-CFU) in bone marrow and spleen indicated dose dependent reduction within 2 days after the irradiation and followed by a slow recovery. Complete recovery took approximately 3 weeks for all functions. GM-CFU in spleen showed the highest sensitivity to all particles indicating a large reduction down to less than 1 % of control at 3 Gy exposured. Of the particle exposed Si (55 keV/mm) induced the largest effects and the slowest recovery, whereas Fe (200 keV/mm) indicated signidicantly the lsast effects and quick recovery. The results suggested a strong LET dependency of the heamatopoietic progenitor cells which may have a RBE maximun less than 100 keV/mm. The recovery kinetics inducated non-monotonic increase within 10 days suggested an involvement of time dependent releases of cytokines (IL-1b ___ IL-3) which may modify the proliferation of hematopoietic cells., 12th International Congress of Radiation Research},
 title = {LET Dependent Recovery of Mouse Hematopoietic Stem Cells from Particle Irradiation},
 year = {2003}
}