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Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation.
https://repo.qst.go.jp/records/55807
https://repo.qst.go.jp/records/558079557d58d-dd2c-4fea-b0e4-213a0c5d7cfe
| Item type | 一般雑誌記事 / Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-12-18 | |||||
| タイトル | ||||||
| タイトル | Relationship between telomere length and radiosensitivity of human cancer cell lines induced by heavy ion irradiation. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Zhang, Hong
× Zhang, Hong× Wang, Yanling× Bing, Wang× Tanaka, Kaoru× Li, Ning× Zhou, Xin× Wang, Zhenhua× Xie, Yi× 王 冰× 田中 薫× Ｗａｎｇ Ｚｈｅｎｈｕａ× Ｘｉｅ Ｙｉ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Our previous works provided evidence that carbon-ion irradiation could repress telomerase activity via BRCA1 regulation in MCF-7 cells. It was proposed that telomerase inhibition could result in telomere shortening, followed by proliferation arrest and cell death. However, telomere shortening was not observed after X-ray or heavy-ion irradiation in our current study. To further understand the regulatory pathway between BRCA1 and telomere, DNA-PKcs, as a downstream effector of BRCA1, was investigated. Inhibition of DNA-PKcs led to significant loss of cell viability via apoptosis and senescence. It was reported that the human telomerase RNA component, hTR, stimulated the kinase activity of DNA-PKcs. These data suggested that the telomerase regulation was mediated by BRCA1 and DNA-PKcs, in-depth investigation about the effect of telomerase activity on radiosensitivity should be carried out. | |||||
| 書誌情報 |
Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC 巻 HIMAC-138, p. 9 3-9 4, 発行日 2012-08 |
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| 出版者 | ||||||
| 出版者 | 放医研 | |||||
