{"created":"2023-05-15T14:40:40.595677+00:00","id":55807,"links":{},"metadata":{"_buckets":{"deposit":"24d284ca-843d-4980-9713-4b05907f0c53"},"_deposit":{"created_by":1,"id":"55807","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"55807"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00055807","sets":["7"]},"author_link":["571048","571056","571049","571057","571051","571055","571054","571058","571052","571053","571047","571050"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-08","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"9 4","bibliographicPageStart":"9 3","bibliographicVolumeNumber":"HIMAC-138","bibliographic_titles":[{"bibliographic_title":"Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Our previous works provided evidence that carbon-ion irradiation  could  repress telomerase activity via BRCA1 regulation in MCF-7 cells. It was proposed that telomerase inhibition could result in telomere shortening, followed by proliferation arrest and cell death. However, telomere shortening was not observed after X-ray or heavy-ion irradiation in our current study. To further understand the regulatory pathway between BRCA1 and telomere, DNA-PKcs, as a downstream effector of BRCA1, was investigated. Inhibition of DNA-PKcs led to significant loss of cell viability via apoptosis and senescence. It was reported that the human telomerase RNA component, hTR, stimulated the kinase activity of DNA-PKcs. These data suggested that the telomerase regulation was mediated by BRCA1 and DNA-PKcs, in-depth investigation about the effect of telomerase activity on radiosensitivity should be carried out.","subitem_description_type":"Abstract"}]},"item_10004_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"放医研"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhang, Hong"}],"nameIdentifiers":[{"nameIdentifier":"571047","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Yanling"}],"nameIdentifiers":[{"nameIdentifier":"571048","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bing, Wang"}],"nameIdentifiers":[{"nameIdentifier":"571049","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"571050","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Ning"}],"nameIdentifiers":[{"nameIdentifier":"571051","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhou, Xin"}],"nameIdentifiers":[{"nameIdentifier":"571052","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wang, Zhenhua"}],"nameIdentifiers":[{"nameIdentifier":"571053","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Xie, Yi"}],"nameIdentifiers":[{"nameIdentifier":"571054","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"571055","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"571056","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｗａｎｇ Ｚｈｅｎｈｕａ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"571057","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｘｉｅ Ｙｉ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"571058","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Relationship between telomere length and  radiosensitivity of human cancer cell lines induced by heavy ion irradiation.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Relationship between telomere length and  radiosensitivity of human cancer cell lines induced by heavy ion irradiation."}]},"item_type_id":"10004","owner":"1","path":["7"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-12-18"},"publish_date":"2012-12-18","publish_status":"0","recid":"55807","relation_version_is_last":true,"title":["Relationship between telomere length and  radiosensitivity of human cancer cell lines induced by heavy ion irradiation."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:45:10.705440+00:00"}