@article{oai:repo.qst.go.jp:00055807,
 author = {Zhang, Hong and Wang, Yanling and Bing, Wang and Tanaka, Kaoru and Li, Ning and Zhou, Xin and Wang, Zhenhua and Xie, Yi and 王 冰 and 田中 薫 and Ｗａｎｇ Ｚｈｅｎｈｕａ and Ｘｉｅ Ｙｉ},
 journal = {Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC},
 month = {Aug},
 note = {Our previous works provided evidence that carbon-ion irradiation  could  repress telomerase activity via BRCA1 regulation in MCF-7 cells. It was proposed that telomerase inhibition could result in telomere shortening, followed by proliferation arrest and cell death. However, telomere shortening was not observed after X-ray or heavy-ion irradiation in our current study. To further understand the regulatory pathway between BRCA1 and telomere, DNA-PKcs, as a downstream effector of BRCA1, was investigated. Inhibition of DNA-PKcs led to significant loss of cell viability via apoptosis and senescence. It was reported that the human telomerase RNA component, hTR, stimulated the kinase activity of DNA-PKcs. These data suggested that the telomerase regulation was mediated by BRCA1 and DNA-PKcs, in-depth investigation about the effect of telomerase activity on radiosensitivity should be carried out.},
 pages = {9 3--9 4},
 title = {Relationship between telomere length and  radiosensitivity of human cancer cell lines induced by heavy ion irradiation.},
 volume = {HIMAC-138},
 year = {2012}
}