炭素線治療効果の早期画像診断法の開発-基礎的研究-（18B253)

X-rays or gamma-rays in the physical and biological
characteristics. On the other hand, radiation to
abdominal cancer, for example the uterus and the
bladder, would cause damages not only to the tumor
but also to the gut nearby target still.
Nuclear medicine imaging for diagnosis, such as
single photon emission computed tomography
(SPECT) and positron emission tomography (PET), has
been applied clinically for the diagnosis of cancer.
Radiotracer is distributed in each organ by the blood
flow. Nevertheless, it has not been established to
evaluate tissue functions in consideration of the
regional blood flow. Especially in irradiated tumors or
normal tissues close to the tumor, the change of blood
flow would be resulted from vascular necrosis by
irradiation. Therefore, these changes should be taken
account for an investigation of tracer accumulation.
Tumor repopulation after carbon-ion irradiation was
estimated using 14C-labeled thymidine as a tracer for
the early response. We demonstrated that the
[2-14C]thymidine uptake in vivo could be an
appropriate marker for early tumor response to
irradiation and correction by blood flow is essential for
the evaluation by [2-14C]thymidine.

書誌情報

放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書

巻 2009, p. 49-50, 発行日 2009-06

出版者

放医研

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2023-05-15 22:46:41.265303

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