@article{oai:repo.qst.go.jp:00055679, author = {高井, 伸彦 and 鵜澤, 玲子 and 平山, 亮一 and 松本, 孔貴 and 安藤, 興一 and 小池, 幸子 and 古澤, 佳也 and その他 and 高井 伸彦 and 鵜澤 玲子 and 平山 亮一 and 松本 孔貴 and 安藤 興一 and 小池 幸子 and 古澤 佳也}, journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書}, month = {Jun}, note = {X-rays or gamma-rays in the physical and biological characteristics. On the other hand, radiation to abdominal cancer, for example the uterus and the bladder, would cause damages not only to the tumor but also to the gut nearby target still. Nuclear medicine imaging for diagnosis, such as single photon emission computed tomography (SPECT) and positron emission tomography (PET), has been applied clinically for the diagnosis of cancer. Radiotracer is distributed in each organ by the blood flow. Nevertheless, it has not been established to evaluate tissue functions in consideration of the regional blood flow. Especially in irradiated tumors or normal tissues close to the tumor, the change of blood flow would be resulted from vascular necrosis by irradiation. Therefore, these changes should be taken account for an investigation of tracer accumulation. Tumor repopulation after carbon-ion irradiation was estimated using 14C-labeled thymidine as a tracer for the early response. We demonstrated that the [2-14C]thymidine uptake in vivo could be an appropriate marker for early tumor response to irradiation and correction by blood flow is essential for the evaluation by [2-14C]thymidine.}, pages = {49--50}, title = {炭素線治療効果の早期画像診断法の開発-基礎的研究-(18B253)}, volume = {2009}, year = {2009} }