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Response of 5 hpf zebrafish embryos to low-dose microbeam protons
https://repo.qst.go.jp/records/54488
https://repo.qst.go.jp/records/544881c15542f-82db-4f74-95cf-0f8fcf14836c
| アイテムタイプ | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-03-06 | |||||
| タイトル | ||||||
| タイトル | Response of 5 hpf zebrafish embryos to low-dose microbeam protons | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Wing, Yan Choi Viann
× Wing, Yan Choi Viann× Yuen, Ping Ng Candy× Kobayashi, Alisa× Konishi, Teruaki× Oikawa, Masakazu× Han, Cheng Shuk× Kwan, Ngok Yu Peter× 小林 亜利紗× 小西 輝昭× 及川 将一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The microbeam irradiation system (single-particle irradiation system to cell, acronym as SPICE) at the National Institute of Radiological Sciences (NIRS), Japan, was employed to irradiate dechorionated embryos of the zebrafish, Danio rerio, at 5 h post-fertilization (hpf) by protons each having an energy of ∼3.4 MeV. Either 1 or 10 positions on the cells were irradiated with different number of protons. The levels of apoptosis in zebrafish embryos at 25 hpf were quantified through terminal dUTP transferase-mediated nick end-labeling assay. Triphasic dose–esponses were obtained (Fig. 1), including (i) a subhormetic zone with an increase in apoptotic signals for a small number of irradiated protons per position, (ii) a hormetic zone with a reduction in the apoptotic signals below the spontaneous level for a larger number of irradiated protons per position and (iii) a toxic zone with an increase in apoptotic signals again if the number of irradiated protons per position was further increased. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 55, 号 S1, p. i113, 発行日 2014-02 |
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| 出版者 | ||||||
| 出版者 | Oxford Journals, Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | doi: 10.1093/jrr/rrt164 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://jrr.oxfordjournals.org/cgi/content/abstract/rrt164? | |||||
| 関連名称 | http://jrr.oxfordjournals.org/cgi/content/abstract/rrt164? | |||||
