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Evidence for Reduced Serotonin Transporter Expression in Posttraumatic Stress Disorder
https://repo.qst.go.jp/records/54230
https://repo.qst.go.jp/records/542302abd56b8-5618-4bcd-b68d-c25b4a12e279
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2010-07-15 | |||||
| タイトル | ||||||
| タイトル | Evidence for Reduced Serotonin Transporter Expression in Posttraumatic Stress Disorder | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Huang, Yiyun
× Huang, Yiyun× Naganawa, Mika× E., Carson Richard× 長縄 美香 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: Although serotonergic dysfunction has been implicated in the pathophysiology of posttraumatic stress disorder (PTSD) and selective serotonin reuptake inhibitors (SSRI's) are widely used in PTSD, the role of the serotonin transporter (SERT) in the neurobiology of PTSD remains unclear. To address this gap we compared expressions of SERT in patients with PTSD and healthy control subjects using the novel SERT radioligand [11C]AFM and positron emission tomography (PET) on a high resolution research tomography (HRRT) PET scanner. Methods: 15 drug-naive patients with PTSD (6 women, age 30.9 +/- 8.3 years;) and 15 individually matched healthy control subjects (HC) (6 women, age 29.7 +/- 10.3 years) were scanned for 120 min with [11C]AFM on the HRRT PET scanner. Individual MRI scans were collected to exclude individuals with anatomical abnormalities and for co-registration. PET imaging data were analyzed using Simplified Reference Tissue Model 2 (SRTM2) to derive regional binding potentials (BP ND). Results: We found reduced SERT BP ND values compared to HC in the left amygdala (1.98 +/- 0.32 versus 2.30 +/- 0.25, p=0.004), left posterior-cingulatecortex (0.38 +/- 0.12 versus 0.55 +/- 0.15, p=0.05) and left superior-frontal-cortex (0.33 +/- 0.08 versus 0.39 +/- 0.09, p=0.03). No between-group differences were found for age/sex/BMI, amount of injected radioactivity/mass, free fraction and cerebellum VT. Conclusions: We show decreased SERT expression in a circuitry that has been consistently implicated in PTSD. These findings are consistent with preclinical models and human genetic studies suggesting that reduced SERT expression is related to higher vulnerability to stress and higher susceptibility to anxiety disorders. |
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| 書誌情報 |
Biological Psychiatry 巻 67, 号 9, supplement 1, p. 208S-208S, 発行日 2010 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006-3223 | |||||
