@inproceedings{oai:repo.qst.go.jp:00054230,
 author = {Huang, Yiyun and Naganawa, Mika and E., Carson Richard and 長縄 美香},
 book = {Biological Psychiatry},
 issue = {9, supplement 1},
 month = {},
 note = {Background: Although serotonergic dysfunction has been implicated in the
pathophysiology of posttraumatic stress disorder (PTSD) and selective
serotonin reuptake inhibitors (SSRI's) are widely used in PTSD, the role of the
serotonin transporter (SERT) in the neurobiology of PTSD remains unclear. To
address this gap we compared expressions of SERT in patients with PTSD and
healthy control subjects using the novel SERT radioligand [11C]AFM and
positron emission tomography (PET) on a high resolution research tomography
(HRRT) PET scanner.
Methods: 15 drug-naive patients with PTSD (6 women, age 30.9 +/- 8.3 years;)
and 15 individually matched healthy control subjects (HC) (6 women, age
29.7 +/- 10.3 years) were scanned for 120 min with [11C]AFM on the HRRT PET
scanner. Individual MRI scans were collected to exclude individuals with
anatomical abnormalities and for co-registration. PET imaging data were
analyzed using Simplified Reference Tissue Model 2 (SRTM2) to derive regional
binding potentials (BP ND).
Results: We found reduced SERT BP ND values compared to HC in the left
amygdala (1.98 +/- 0.32 versus 2.30 +/- 0.25, p=0.004), left posterior-cingulatecortex
(0.38 +/- 0.12 versus 0.55 +/- 0.15, p=0.05) and left superior-frontal-cortex
(0.33 +/- 0.08 versus 0.39 +/- 0.09, p=0.03). No between-group differences were
found for age/sex/BMI, amount of injected radioactivity/mass, free fraction
and cerebellum VT.
Conclusions: We show decreased SERT expression in a circuitry that has
been consistently implicated in PTSD. These findings are consistent with
preclinical models and human genetic studies suggesting that reduced SERT
expression is related to higher vulnerability to stress and higher susceptibility
to anxiety disorders.},
 pages = {208S--208S},
 title = {Evidence for Reduced Serotonin Transporter Expression in Posttraumatic Stress Disorder},
 volume = {67},
 year = {2010}
}