{"created":"2023-05-15T14:39:29.074536+00:00","id":54230,"links":{},"metadata":{"_buckets":{"deposit":"6e528fb4-dbd6-41b2-bd8e-ce7438f67f7b"},"_deposit":{"created_by":1,"id":"54230","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"54230"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00054230","sets":["2"]},"author_link":["553731","553730","553732","553729"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9, supplement 1","bibliographicPageEnd":"208S","bibliographicPageStart":"208S","bibliographicVolumeNumber":"67","bibliographic_titles":[{"bibliographic_title":"Biological Psychiatry"}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Although serotonergic dysfunction has been implicated in the\npathophysiology of posttraumatic stress disorder (PTSD) and selective\nserotonin reuptake inhibitors (SSRI's) are widely used in PTSD, the role of the\nserotonin transporter (SERT) in the neurobiology of PTSD remains unclear. To\naddress this gap we compared expressions of SERT in patients with PTSD and\nhealthy control subjects using the novel SERT radioligand [11C]AFM and\npositron emission tomography (PET) on a high resolution research tomography\n(HRRT) PET scanner.\nMethods: 15 drug-naive patients with PTSD (6 women, age 30.9 +/- 8.3 years;)\nand 15 individually matched healthy control subjects (HC) (6 women, age\n29.7 +/- 10.3 years) were scanned for 120 min with [11C]AFM on the HRRT PET\nscanner. Individual MRI scans were collected to exclude individuals with\nanatomical abnormalities and for co-registration. PET imaging data were\nanalyzed using Simplified Reference Tissue Model 2 (SRTM2) to derive regional\nbinding potentials (BP ND).\nResults: We found reduced SERT BP ND values compared to HC in the left\namygdala (1.98 +/- 0.32 versus 2.30 +/- 0.25, p=0.004), left posterior-cingulatecortex\n(0.38 +/- 0.12 versus 0.55 +/- 0.15, p=0.05) and left superior-frontal-cortex\n(0.33 +/- 0.08 versus 0.39 +/- 0.09, p=0.03). No between-group differences were\nfound for age/sex/BMI, amount of injected radioactivity/mass, free fraction\nand cerebellum VT.\nConclusions: We show decreased SERT expression in a circuitry that has\nbeen consistently implicated in PTSD. These findings are consistent with\npreclinical models and human genetic studies suggesting that reduced SERT\nexpression is related to higher vulnerability to stress and higher susceptibility\nto anxiety disorders.","subitem_description_type":"Abstract"}]},"item_10003_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-3223","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Huang, Yiyun"}],"nameIdentifiers":[{"nameIdentifier":"553729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naganawa, Mika"}],"nameIdentifiers":[{"nameIdentifier":"553730","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"E., Carson Richard"}],"nameIdentifiers":[{"nameIdentifier":"553731","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長縄 美香","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"553732","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"Evidence for Reduced Serotonin Transporter Expression in Posttraumatic Stress Disorder","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evidence for Reduced Serotonin Transporter Expression in Posttraumatic Stress Disorder"}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-07-15"},"publish_date":"2010-07-15","publish_status":"0","recid":"54230","relation_version_is_last":true,"title":["Evidence for Reduced Serotonin Transporter Expression in Posttraumatic Stress Disorder"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:03:24.721204+00:00"}