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Enhancement of gene silencing potency and nuclease stability by chemically modified duplex RNA
https://repo.qst.go.jp/records/53944
https://repo.qst.go.jp/records/5394410866f55-baf9-4922-99f3-d45f53a4631d
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-05-02 | |||||
| タイトル | ||||||
| タイトル | Enhancement of gene silencing potency and nuclease stability by chemically modified duplex RNA | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kubo, Takanori
× Kubo, Takanori× Zhelev, Zhivko× Bakalova-Zheleva, Rumiana× Ohba, Hideki× バカロバ ルミアナ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In this study, we describe a development of chemically modified dsRNAs with improved biological properties. These dsRNAs possess an enhanced RNAi activity and a dramatically increased stability in cell cultured medium (containing 10% serum) in comparison with widely used 21nt siRNA. The chemically modified dsRNAs manifested a high longterm gene suppression after one week post-transfection, whereas 21nt siRNA showed a high RNAi activity only after 48 h cell transfection. | |||||
| 書誌情報 |
Nucleic Acids Symposium Series 号 51, p. 407-408, 発行日 2007-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0261-3166 | |||||
