{"created":"2023-05-15T14:39:16.411434+00:00","id":53944,"links":{},"metadata":{"_buckets":{"deposit":"ece0c1f3-71ce-415d-b3dc-0cdc2a26e7b3"},"_deposit":{"created_by":1,"id":"53944","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"53944"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00053944","sets":["2"]},"author_link":["550478","550480","550477","550476","550479"],"item_10003_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"51","bibliographicPageEnd":"408","bibliographicPageStart":"407","bibliographic_titles":[{"bibliographic_title":"Nucleic Acids Symposium Series"}]}]},"item_10003_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study, we describe a development of chemically modified dsRNAs with improved biological properties. These dsRNAs possess an enhanced RNAi activity and a dramatically increased stability in cell cultured medium (containing 10% serum) in comparison with widely used 21nt siRNA. The chemically modified dsRNAs manifested a high longterm gene suppression after one week post-transfection, whereas 21nt siRNA showed a high RNAi activity only after 48 h cell transfection.","subitem_description_type":"Abstract"}]},"item_10003_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0261-3166","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kubo, Takanori"}],"nameIdentifiers":[{"nameIdentifier":"550476","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhelev, Zhivko"}],"nameIdentifiers":[{"nameIdentifier":"550477","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova-Zheleva, Rumiana"}],"nameIdentifiers":[{"nameIdentifier":"550478","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohba, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"550479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"バカロバ ルミアナ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"550480","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference paper","resourceuri":"http://purl.org/coar/resource_type/c_5794"}]},"item_title":"Enhancement of gene silencing potency and nuclease stability by chemically modified duplex RNA","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Enhancement of gene silencing potency and nuclease stability by chemically modified duplex RNA"}]},"item_type_id":"10003","owner":"1","path":["2"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-05-02"},"publish_date":"2008-05-02","publish_status":"0","recid":"53944","relation_version_is_last":true,"title":["Enhancement of gene silencing potency and nuclease stability by chemically modified duplex RNA"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:06:41.896913+00:00"}