@inproceedings{oai:repo.qst.go.jp:00053944, author = {Kubo, Takanori and Zhelev, Zhivko and Bakalova-Zheleva, Rumiana and Ohba, Hideki and バカロバ ルミアナ}, book = {Nucleic Acids Symposium Series}, issue = {51}, month = {Nov}, note = {In this study, we describe a development of chemically modified dsRNAs with improved biological properties. These dsRNAs possess an enhanced RNAi activity and a dramatically increased stability in cell cultured medium (containing 10% serum) in comparison with widely used 21nt siRNA. The chemically modified dsRNAs manifested a high longterm gene suppression after one week post-transfection, whereas 21nt siRNA showed a high RNAi activity only after 48 h cell transfection.}, pages = {407--408}, title = {Enhancement of gene silencing potency and nuclease stability by chemically modified duplex RNA}, year = {2007} }