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Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect.
https://repo.qst.go.jp/records/49391
https://repo.qst.go.jp/records/493913c60310d-4d9e-4c8f-8eef-daa3084831bf
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-01-04 | |||||
| タイトル | ||||||
| タイトル | Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ivanova, Donika
× Ivanova, Donika× Zhelev, Zhivko× Getsov, Plamen× Nikolova, Biliana× Aoki, Ichio× Higashi, Tatsuya× Bakalova, Rumiana× Aoki, Ichio× Higashi, Tatsuya× Bakalova, Rumiana |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This review is directed to the redox-modulating properties and anticancer effect of vitamin K. The concept is focused on two aspects: (i) redox-cycle of vitamin K and its effect on the calcium homeostasis, "oncogenic" and "onco-suppressive" reactive oxygen species and the specific induction of oxidative stress in cancer; (ii) vitamin K plus C as a powerful redox-system, which forms a bypass between mitochondrial complexes II and III and thus prevents mitochondrial dysfunction, restores oxidative phosphorylation and aerobic glycolysis, modulates the redox-state of endogenous redox-pairs, eliminates the hypoxic environment of cancer cells and induces cell death. The analyzed data suggest that vitamin C&K can sensitize cancer cells to conventional chemotherapy, which allows achievement of a lower effective dose of the drug and minimizing the harmful side-effects. The review is intended for a wide audience of readers - from students to specialists in the field. | |||||
| 書誌情報 |
Redox biology 巻 16, p. 352-358, 発行日 2018-01 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2213-2317 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29597144 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.redox.2018.03.013 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S2213231718300934 | |||||
