@article{oai:repo.qst.go.jp:00049391,
 author = {Ivanova, Donika and Zhelev, Zhivko and Getsov, Plamen and Nikolova, Biliana and Aoki, Ichio and Higashi, Tatsuya and Bakalova, Rumiana and Aoki, Ichio and Higashi, Tatsuya and Bakalova, Rumiana},
 journal = {Redox biology},
 month = {Jan},
 note = {This review is directed to the redox-modulating properties and anticancer effect of vitamin K. The concept is focused on two aspects: (i) redox-cycle of vitamin K and its effect on the calcium homeostasis, "oncogenic" and "onco-suppressive" reactive oxygen species and the specific induction of oxidative stress in cancer; (ii) vitamin K plus C as a powerful redox-system, which forms a bypass between mitochondrial complexes II and III and thus prevents mitochondrial dysfunction, restores oxidative phosphorylation and aerobic glycolysis, modulates the redox-state of endogenous redox-pairs, eliminates the hypoxic environment of cancer cells and induces cell death. The analyzed data suggest that vitamin C&K can sensitize cancer cells to conventional chemotherapy, which allows achievement of a lower effective dose of the drug and minimizing the harmful side-effects. The review is intended for a wide audience of readers - from students to specialists in the field.},
 pages = {352--358},
 title = {Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect.},
 volume = {16},
 year = {2018}
}