{"created":"2023-05-15T14:38:16.448099+00:00","id":49391,"links":{},"metadata":{"_buckets":{"deposit":"9c7d513c-f4cc-4fe8-a00f-bceca1169d46"},"_deposit":{"created_by":1,"id":"49391","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49391"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049391","sets":["1"]},"author_link":["798594","798600","798601","798597","798603","798599","798598","798595","798602","798596"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"358","bibliographicPageStart":"352","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"Redox biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This review is directed to the redox-modulating properties and anticancer effect of vitamin K. The concept is focused on two aspects: (i) redox-cycle of vitamin K and its effect on the calcium homeostasis, \"oncogenic\" and \"onco-suppressive\" reactive oxygen species and the specific induction of oxidative stress in cancer; (ii) vitamin K plus C as a powerful redox-system, which forms a bypass between mitochondrial complexes II and III and thus prevents mitochondrial dysfunction, restores oxidative phosphorylation and aerobic glycolysis, modulates the redox-state of endogenous redox-pairs, eliminates the hypoxic environment of cancer cells and induces cell death. The analyzed data suggest that vitamin C&K can sensitize cancer cells to conventional chemotherapy, which allows achievement of a lower effective dose of the drug and minimizing the harmful side-effects. The review is intended for a wide audience of readers - from students to specialists in the field.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29597144","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.redox.2018.03.013","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/pii/S2213231718300934","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2213-2317","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ivanova, Donika"}],"nameIdentifiers":[{"nameIdentifier":"798594","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhelev, Zhivko"}],"nameIdentifiers":[{"nameIdentifier":"798595","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Getsov, Plamen"}],"nameIdentifiers":[{"nameIdentifier":"798596","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nikolova, Biliana"}],"nameIdentifiers":[{"nameIdentifier":"798597","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"798598","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"798599","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova, Rumiana"}],"nameIdentifiers":[{"nameIdentifier":"798600","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"798601","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashi, Tatsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"798602","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova, Rumiana","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"798603","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-01-04"},"publish_date":"2019-01-04","publish_status":"0","recid":"49391","relation_version_is_last":true,"title":["Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:51:12.314679+00:00"}