WEKO3
アイテム
Single fraction carbon ion radiotherapy for colorectal cancer liver metastasis:A dose escalation study.
https://repo.qst.go.jp/records/49387
https://repo.qst.go.jp/records/493870f232a7e-5792-4f80-99ac-3852c017f4a4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-11-27 | |||||
| タイトル | ||||||
| タイトル | Single fraction carbon ion radiotherapy for colorectal cancer liver metastasis:A dose escalation study. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Makishima, Hirokazu
× Makishima, Hirokazu× Yasuda, Shigeo× Isozaki, Yuka× Kasuya, Goro× Okada, Naomi× Miyazaki, Masaru× Mohamad, Osama× Matsufuji, Naruhiro× Yamada, Shigeru× Tsuji, Hiroshi× Kamada, Tadashi× Liver Cancer Working Group, the× Makishima, Hirokazu× Yasuda, Shigeo× Isozaki, Yuka× Kasuya, Goro× Okada, Naomi× Miyazaki, Masaru× Matsufuji, Naruhiro× Yamada, Shigeru× Tsuji, Hiroshi× Kamada, Tadashi |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Prognosis is usually grim for those who cannot receive resection with liver metastasis from colorectal cancer (CRC). Radiation therapy can be an option for those unsuitable for resection, and carbon-ion radiotherapy (CIRT) would be expected higher effective and less toxic than X-ray due to its physio-biological characteristics. The objective of this study is to identify the optimal dose of single fraction CIRT for colorectal cancer liver metastasis. Thirty-one patients with liver metastasis from CRC were enrolled. Twenty-nine patients received a single-fraction CIRT, escalating dose from 36 Gy (RBE) in 5 to 10% increments until unacceptable incidence of dose-limiting toxicity is observed. Dose-limiting toxicity was defined as grade ≥ 3 acute toxicity attributed to radiotherapy. The prescribed doses were: 36 Gy (RBE) (3 cases), 40 (2), 44 (4), 46 (6), 48 (3), 53 (8), and 58 (3). Dose-limiting toxicity was not observed but late grade 3 liver toxicity due to biliary obstruction was observed in 2 patients at 53 Gy (RBE). Both cases had lesions close to the hepatic portal region, and therefore dose was escalated to 58 Gy (RBE) limited to peripheral lesions. Three-year actuarial overall survival rate of all 29 patients was 78%, and median survival time was 65 months. Local control improved significantly at ≥53 Gy (RBE), with 3-year actuarial local control rate of 82%, compared to 28% in lower doses. Treatment for CRC liver metastasis with single-fraction CIRT appeared to be safe up to 58Gy (RBE) as long as the central hepatic portal region is avoided. This article is protected by copyright. All rights reserved. | |||||
| 書誌情報 |
Cancer science 巻 110, 号 1, p. 303-309, 発行日 2018-11 |
|||||
| 出版者 | ||||||
| 出版者 | Wiley Publishing on behalf of the Japanese Cancer Association | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1347-9032 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 30417485 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/cas.13872 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/epdf/10.1111/cas.13872 | |||||
