{"created":"2023-05-15T14:38:16.181292+00:00","id":49387,"links":{},"metadata":{"_buckets":{"deposit":"d945b57c-895e-467d-950d-550ee3cfefd1"},"_deposit":{"created_by":1,"id":"49387","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"49387"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00049387","sets":["1"]},"author_link":["839866","839870","839865","839864","839867","839863","839856","839860","839861","839855","839852","839869","839873","839872","839858","839853","839854","839871","839857","839862","839868","839859"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"309","bibliographicPageStart":"303","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"Cancer science"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Prognosis is usually grim for those who cannot receive resection with liver metastasis from colorectal cancer (CRC). Radiation therapy can be an option for those unsuitable for resection, and carbon-ion radiotherapy (CIRT) would be expected higher effective and less toxic than X-ray due to its physio-biological characteristics. The objective of this study is to identify the optimal dose of single fraction CIRT for colorectal cancer liver metastasis. Thirty-one patients with liver metastasis from CRC were enrolled. Twenty-nine patients received a single-fraction CIRT, escalating dose from 36 Gy (RBE) in 5 to 10% increments until unacceptable incidence of dose-limiting toxicity is observed. Dose-limiting toxicity was defined as grade ≥ 3 acute toxicity attributed to radiotherapy. The prescribed doses were: 36 Gy (RBE) (3 cases), 40 (2), 44 (4), 46 (6), 48 (3), 53 (8), and 58 (3). Dose-limiting toxicity was not observed but late grade 3 liver toxicity due to biliary obstruction was observed in 2 patients at 53 Gy (RBE). Both cases had lesions close to the hepatic portal region, and therefore dose was escalated to 58 Gy (RBE) limited to peripheral lesions. Three-year actuarial overall survival rate of all 29 patients was 78%, and median survival time was 65 months. Local control improved significantly at ≥53 Gy (RBE), with 3-year actuarial local control rate of 82%, compared to 28% in lower doses. Treatment for CRC liver metastasis with single-fraction CIRT appeared to be safe up to 58Gy (RBE) as long as the central hepatic portal region is avoided. This article is protected by copyright. All rights reserved.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley Publishing on behalf of the Japanese Cancer Association"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"30417485","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/cas.13872","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cas.13872","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-9032","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Makishima, Hirokazu"}],"nameIdentifiers":[{"nameIdentifier":"839852","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Shigeo"}],"nameIdentifiers":[{"nameIdentifier":"839853","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Isozaki, Yuka"}],"nameIdentifiers":[{"nameIdentifier":"839854","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kasuya, Goro"}],"nameIdentifiers":[{"nameIdentifier":"839855","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, Naomi"}],"nameIdentifiers":[{"nameIdentifier":"839856","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyazaki, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"839857","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mohamad, Osama"}],"nameIdentifiers":[{"nameIdentifier":"839858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsufuji, Naruhiro"}],"nameIdentifiers":[{"nameIdentifier":"839859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru"}],"nameIdentifiers":[{"nameIdentifier":"839860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"839861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi"}],"nameIdentifiers":[{"nameIdentifier":"839862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Liver Cancer Working Group, the"}],"nameIdentifiers":[{"nameIdentifier":"839863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Makishima, Hirokazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839864","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasuda, Shigeo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839865","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Isozaki, Yuka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kasuya, Goro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839867","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, Naomi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839868","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyazaki, Masaru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839869","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsufuji, Naruhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839870","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Shigeru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839871","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839872","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamada, Tadashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"839873","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Single fraction carbon ion radiotherapy for colorectal cancer liver metastasis:A dose escalation study.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Single fraction carbon ion radiotherapy for colorectal cancer liver metastasis:A dose escalation study."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-11-27"},"publish_date":"2018-11-27","publish_status":"0","recid":"49387","relation_version_is_last":true,"title":["Single fraction carbon ion radiotherapy for colorectal cancer liver metastasis:A dose escalation study."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:47:14.561024+00:00"}