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Reduced gray matter volume is correlated with frontal cognitive and behavioral impairments in Parkinson's disease
https://repo.qst.go.jp/records/48986
https://repo.qst.go.jp/records/4898623a1d59c-5246-4c5a-abc2-748501720671
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-05-15 | |||||
| タイトル | ||||||
| タイトル | Reduced gray matter volume is correlated with frontal cognitive and behavioral impairments in Parkinson's disease | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Terada, Tatsuhiro
× Terada, Tatsuhiro× Miyata, Jun× Obi, Tomokazu× Kubota, Manabu× Yoshizumi, Miho× Murai, Toshiya× Kubota, Manabu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: To identify the brain-volume reductions associated with frontal cognitive and behavioral impairments in Parkinson's disease (PD). Methods: Forty PD patients without dementia or amnesia (Hoehn and Yahr stage 3) and 10 age-matched controls underwent brain magnetic resonance imaging. Cognitive and behavioral impairments were assessed by using the Frontal Assessment Battery (FAB) and Frontal Systems Behavioral Scale (FrSBe), respectively. We applied voxelbased morphometry to investigate the correlations of regional gray matter volume with FAB, FrSBe, and physical disability. Results: FAB was significantly lower in PD than in controls. FrSBe was significantly higher after PD onset than before, notably in the apathy subscale. FAB and FrSBe were significantly intercorrelated. In PD patients, left inferior frontal volume was positively correlated with FAB, whereas right precentral volume was negatively correlated with FrSBe total score. The brain volumes in both of these regions were not correlated with the Unified PD Rating Scale III. Conclusion: Behavioral impairments in PD tended to coexist with progression of frontal cognitive impairment. Regional atrophy within the frontal lobe was associated with both frontal cognitive and behavioral impairments. However, the specific region responsible for behavioral impairment differed from that for frontal cognitive impairment. These associations were independent of physical disability. |
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| 書誌情報 |
Journal of the Neurological Sciences 巻 390, p. 231-238, 発行日 2018-07 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0022-510X | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 29801896 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.jns.2018.05.005 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/abs/pii/S0022510X18302193 | |||||
