{"created":"2023-05-15T14:37:58.546709+00:00","id":48986,"links":{},"metadata":{"_buckets":{"deposit":"e6d651ba-f564-423a-8210-4bff837a1fcd"},"_deposit":{"created_by":1,"id":"48986","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48986"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048986","sets":["1"]},"author_link":["865065","865062","865064","865063","865068","865067","865066"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-07","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"238","bibliographicPageStart":"231","bibliographicVolumeNumber":"390","bibliographic_titles":[{"bibliographic_title":"Journal of the Neurological Sciences"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: To identify the brain-volume reductions associated with frontal cognitive and behavioral impairments\nin Parkinson's disease (PD).\nMethods: Forty PD patients without dementia or amnesia (Hoehn and Yahr stage 3) and 10 age-matched controls\nunderwent brain magnetic resonance imaging. Cognitive and behavioral impairments were assessed by using the\nFrontal Assessment Battery (FAB) and Frontal Systems Behavioral Scale (FrSBe), respectively. We applied voxelbased\nmorphometry to investigate the correlations of regional gray matter volume with FAB, FrSBe, and physical\ndisability.\nResults: FAB was significantly lower in PD than in controls. FrSBe was significantly higher after PD onset than\nbefore, notably in the apathy subscale. FAB and FrSBe were significantly intercorrelated. In PD patients, left\ninferior frontal volume was positively correlated with FAB, whereas right precentral volume was negatively\ncorrelated with FrSBe total score. The brain volumes in both of these regions were not correlated with the\nUnified PD Rating Scale III.\nConclusion: Behavioral impairments in PD tended to coexist with progression of frontal cognitive impairment.\nRegional atrophy within the frontal lobe was associated with both frontal cognitive and behavioral impairments.\nHowever, the specific region responsible for behavioral impairment differed from that for frontal cognitive\nimpairment. These associations were independent of physical disability.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"29801896","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jns.2018.05.005","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.sciencedirect.com/science/article/abs/pii/S0022510X18302193","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":" 0022-510X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Terada, Tatsuhiro"}],"nameIdentifiers":[{"nameIdentifier":"865062","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyata, Jun"}],"nameIdentifiers":[{"nameIdentifier":"865063","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Obi, Tomokazu"}],"nameIdentifiers":[{"nameIdentifier":"865064","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubota, Manabu"}],"nameIdentifiers":[{"nameIdentifier":"865065","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshizumi, Miho"}],"nameIdentifiers":[{"nameIdentifier":"865066","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murai, Toshiya"}],"nameIdentifiers":[{"nameIdentifier":"865067","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubota, Manabu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"865068","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Reduced gray matter volume is correlated with frontal cognitive and behavioral impairments in Parkinson's disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Reduced gray matter volume is correlated with frontal cognitive and behavioral impairments in Parkinson's disease"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-05-15"},"publish_date":"2018-05-15","publish_status":"0","recid":"48986","relation_version_is_last":true,"title":["Reduced gray matter volume is correlated with frontal cognitive and behavioral impairments in Parkinson's disease"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:59:19.602176+00:00"}