@article{oai:repo.qst.go.jp:00048986,
 author = {Terada, Tatsuhiro and Miyata, Jun and Obi, Tomokazu and Kubota, Manabu and Yoshizumi, Miho and Murai, Toshiya and Kubota, Manabu},
 journal = {Journal of the Neurological Sciences},
 month = {Jul},
 note = {Objective: To identify the brain-volume reductions associated with frontal cognitive and behavioral impairments
in Parkinson's disease (PD).
Methods: Forty PD patients without dementia or amnesia (Hoehn and Yahr stage 3) and 10 age-matched controls
underwent brain magnetic resonance imaging. Cognitive and behavioral impairments were assessed by using the
Frontal Assessment Battery (FAB) and Frontal Systems Behavioral Scale (FrSBe), respectively. We applied voxelbased
morphometry to investigate the correlations of regional gray matter volume with FAB, FrSBe, and physical
disability.
Results: FAB was significantly lower in PD than in controls. FrSBe was significantly higher after PD onset than
before, notably in the apathy subscale. FAB and FrSBe were significantly intercorrelated. In PD patients, left
inferior frontal volume was positively correlated with FAB, whereas right precentral volume was negatively
correlated with FrSBe total score. The brain volumes in both of these regions were not correlated with the
Unified PD Rating Scale III.
Conclusion: Behavioral impairments in PD tended to coexist with progression of frontal cognitive impairment.
Regional atrophy within the frontal lobe was associated with both frontal cognitive and behavioral impairments.
However, the specific region responsible for behavioral impairment differed from that for frontal cognitive
impairment. These associations were independent of physical disability.},
 pages = {231--238},
 title = {Reduced gray matter volume is correlated with frontal cognitive and behavioral impairments in Parkinson's disease},
 volume = {390},
 year = {2018}
}