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A Strategy to Design Hyperpolarized 13 C Magnetic Resonance Probes Using [1-13 C]α-Amino Acid as a Scaffold Structure
https://repo.qst.go.jp/records/48778
https://repo.qst.go.jp/records/48778e5d003ad-ad6e-4e88-9358-c351b0a6ef59
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-23 | |||||
| タイトル | ||||||
| タイトル | A Strategy to Design Hyperpolarized 13 C Magnetic Resonance Probes Using [1-13 C]α-Amino Acid as a Scaffold Structure | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nishihara, Tatsuya
× Nishihara, Tatsuya× Kameyama, Yutaka× Nonaka, Hiroshi× Takakusagi, Yoichi× Hyodo, Fuminori× Ichikawa, Kazuhiro× Sando, Shinsuke× 高草木 洋一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Hyperpolarization is an emerging method that dramatically enhances NMR signal intensity. As a result of their increased sensitivity, hyperpolarized (HP) NMR molecular probes can be used to perform time-resolved spectroscopy and imaging in vitro and in vivo. It is, however, challenging to design such probes de novo. Herein, the [1-13C]a-amino acid is reported as a scaffold structure to design HP 13C NMR molecular probes. The [1-13C]a-amino acid can be converted to various HP 13C chemical probes that show sufficient chemical shift change by altering the chemical state of the a nitrogen upon interaction with the target. Several previously reported HP probes could be explained by this design principle. To demonstrate the versatility of this approach, two a-amino-acid-based HP 13C chemical probes, sensitive to pH and Ca2+ ion, were developed and used to detect targets. | |||||
| 書誌情報 |
Chemistry − An Asian Journal 巻 12, 号 9, p. 949-953, 発行日 2017-04 |
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| 出版者 | ||||||
| 出版者 | Wiley | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1861-4728 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 28328174 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/asia.201700098 | |||||
