@article{oai:repo.qst.go.jp:00048778,
 author = {Nishihara, Tatsuya and Kameyama, Yutaka and Nonaka, Hiroshi and Takakusagi, Yoichi and Hyodo, Fuminori and Ichikawa, Kazuhiro and Sando, Shinsuke and 高草木 洋一},
 issue = {9},
 journal = {Chemistry − An Asian Journal},
 month = {Apr},
 note = {Hyperpolarization is an emerging method that dramatically enhances NMR signal intensity. As a result of their increased sensitivity, hyperpolarized (HP) NMR molecular probes can be used to perform time-resolved spectroscopy and imaging in vitro and in vivo. It is, however, challenging to design such probes de novo. Herein, the [1-13C]a-amino acid is reported as a scaffold structure to design HP 13C NMR molecular probes. The [1-13C]a-amino acid can be converted to various HP 13C chemical probes that show sufficient chemical shift change by altering the chemical state of the a nitrogen upon interaction with the target. Several previously reported HP probes could be explained by this design principle. To demonstrate the versatility of this approach, two a-amino-acid-based HP 13C chemical probes, sensitive to pH and Ca2+ ion, were developed and used to detect targets.},
 pages = {949--953},
 title = {A Strategy to Design Hyperpolarized 13 C Magnetic Resonance Probes Using [1-13 C]α-Amino Acid as a Scaffold Structure},
 volume = {12},
 year = {2017}
}