{"created":"2023-05-15T14:37:48.379374+00:00","id":48778,"links":{},"metadata":{"_buckets":{"deposit":"87a73f44-0b3d-4a95-9c9a-3732268448dc"},"_deposit":{"created_by":1,"id":"48778","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48778"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048778","sets":["1"]},"author_link":["491125","491123","491128","491126","491129","491127","491122","491124"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"953","bibliographicPageStart":"949","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Chemistry − An Asian Journal"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hyperpolarization is an emerging method that dramatically enhances NMR signal intensity. As a result of their increased sensitivity, hyperpolarized (HP) NMR molecular probes can be used to perform time-resolved spectroscopy and imaging in vitro and in vivo. It is, however, challenging to design such probes de novo. Herein, the [1-13C]a-amino acid is reported as a scaffold structure to design HP 13C NMR molecular probes. The [1-13C]a-amino acid can be converted to various HP 13C chemical probes that show sufficient chemical shift change by altering the chemical state of the a nitrogen upon interaction with the target. Several previously reported HP probes could be explained by this design principle. To demonstrate the versatility of this approach, two a-amino-acid-based HP 13C chemical probes, sensitive to pH and Ca2+ ion, were developed and used to detect targets.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"28328174","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/asia.201700098","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1861-4728","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishihara, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"491122","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kameyama, Yutaka"}],"nameIdentifiers":[{"nameIdentifier":"491123","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nonaka, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"491124","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takakusagi, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"491125","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hyodo, Fuminori"}],"nameIdentifiers":[{"nameIdentifier":"491126","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichikawa, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"491127","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sando, Shinsuke"}],"nameIdentifiers":[{"nameIdentifier":"491128","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高草木 洋一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"491129","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Strategy to Design Hyperpolarized 13 C Magnetic Resonance Probes Using [1-13 C]α-Amino Acid as a Scaffold Structure","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Strategy to Design Hyperpolarized 13 C Magnetic Resonance Probes Using [1-13 C]α-Amino Acid as a Scaffold Structure"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-23"},"publish_date":"2018-04-23","publish_status":"0","recid":"48778","relation_version_is_last":true,"title":["A Strategy to Design Hyperpolarized 13 C Magnetic Resonance Probes Using [1-13 C]α-Amino Acid as a Scaffold Structure"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:24:24.648078+00:00"}