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Cytotoxic and genotoxic potential of Bulgarian Rosa alba L. essential oil – in vitro model study
https://repo.qst.go.jp/records/48763
https://repo.qst.go.jp/records/487639438862c-d52c-4ac7-a972-1303c8cad4aa
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2018-04-20 | |||||
| タイトル | ||||||
| タイトル | Cytotoxic and genotoxic potential of Bulgarian Rosa alba L. essential oil – in vitro model study | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Jovtchev, Gabrielle
× Jovtchev, Gabrielle× Stankov, Alexander× Georgieva, Almira× Dobreva, Anna× Bakalova, Rumiana× Aoki, Ichio× Mileva, Milka× バカロバ ルミアナ× 青木 伊知男 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background/Aim: Rose alba L. also known as the white oil-bearing rose, has been cultivated in relatively small areas of Europe – predominantly in the Rose Valley of Bulgaria. The essential rose oils of Rosa alba L. is among the most expensive products on the world markets. In the last years, an increasing number of studies in vitro and in vivo, including clinical studies, have demonstrated a therapeutic efficacy of rose oils. However, little is known about the cytotoxic and genotoxic potential of the phytocomplex oil extract, derived from Rosa alba L., and its constituents. The aim of the present work was to investigate cytotoxicity and clastogenic effects of Rosa alba L. essential oil and its main constituents – geraniol and citral. Methods: We used classical cytogenetic methods and comet assay. 1- Methyl-3-nitro-1-nitrosoguanidine was used as a standard mutagen. Results: The data show that Rose alba L. essential oil (in concentrations up to 1000 g/ml) did not exhibit a statistically significant cytotoxic effect. The oil extract did not increase significantly the level of mitotic disturbances (micronuclei and aneuploidy effects) and has no significant effect on the induction of chromatid aberrations, compared to the untreated control sample. Only geraniol and citral (in concentrations used) increased significantly the percentage of migrated DNA in the comet tail, compared to the whole oil extract. Conclusion: This study gives a reason to believe that rose oils and some of their constituents have a potential as supplementary components in anticancer therapy. They would be harmless to normal cells and tissues, but with potential for additive or synergistic cytotoxicity against cancer cells. |
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| 書誌情報 |
Biotechnology & Biotechnological Equipment 巻 32, 号 2, 発行日 2018-01 |
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| 出版者 | ||||||
| 出版者 | Taylor & Francis | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1314-3530 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1080/13102818.2017.1423245 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | 10.1080/13102818.2017.1423245 | |||||
| 関連名称 | 10.1080/13102818.2017.1423245 | |||||
