{"created":"2023-05-15T14:37:47.715481+00:00","id":48763,"links":{},"metadata":{"_buckets":{"deposit":"2cae950d-ed2f-4dd2-9874-11576060308f"},"_deposit":{"created_by":1,"id":"48763","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"48763"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00048763","sets":["1"]},"author_link":["490930","490922","490925","490929","490926","490927","490924","490928","490923"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"Biotechnology & Biotechnological Equipment"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Aim: Rose alba L. also known as the white oil-bearing rose, has been cultivated\nin relatively small areas of Europe – predominantly in the Rose Valley of Bulgaria. The\nessential rose oils of Rosa alba L. is among the most expensive products on the world\nmarkets. In the last years, an increasing number of studies in vitro and in vivo, including\nclinical studies, have demonstrated a therapeutic efficacy of rose oils. However, little is\nknown about the cytotoxic and genotoxic potential of the phytocomplex oil extract, derived\nfrom Rosa alba L., and its constituents. The aim of the present work was to investigate\ncytotoxicity and clastogenic effects of Rosa alba L. essential oil and its main constituents –\ngeraniol and citral. Methods: We used classical cytogenetic methods and comet assay. 1-\nMethyl-3-nitro-1-nitrosoguanidine was used as a standard mutagen. Results: The data show\nthat Rose alba L. essential oil (in concentrations up to 1000 g/ml) did not exhibit a\nstatistically significant cytotoxic effect. The oil extract did not increase significantly the level\nof mitotic disturbances (micronuclei and aneuploidy effects) and has no significant effect on the induction of chromatid aberrations, compared to the untreated control sample. Only\ngeraniol and citral (in concentrations used) increased significantly the percentage of migrated\nDNA in the comet tail, compared to the whole oil extract. Conclusion: This study gives a\nreason to believe that rose oils and some of their constituents have a potential as\nsupplementary components in anticancer therapy. They would be harmless to normal cells and\ntissues, but with potential for additive or synergistic cytotoxicity against cancer cells.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1080/13102818.2017.1423245","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"10.1080/13102818.2017.1423245"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1080/13102818.2017.1423245","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1314-3530","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Jovtchev, Gabrielle"}],"nameIdentifiers":[{"nameIdentifier":"490922","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Stankov, Alexander"}],"nameIdentifiers":[{"nameIdentifier":"490923","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Georgieva, Almira"}],"nameIdentifiers":[{"nameIdentifier":"490924","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Dobreva, Anna"}],"nameIdentifiers":[{"nameIdentifier":"490925","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova, Rumiana"}],"nameIdentifiers":[{"nameIdentifier":"490926","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"490927","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mileva, Milka"}],"nameIdentifiers":[{"nameIdentifier":"490928","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"バカロバ ルミアナ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"490929","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"490930","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Cytotoxic and genotoxic potential of Bulgarian Rosa alba L. essential oil – in vitro model study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cytotoxic and genotoxic potential of Bulgarian Rosa alba L. essential oil – in vitro model study"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-04-20"},"publish_date":"2018-04-20","publish_status":"0","recid":"48763","relation_version_is_last":true,"title":["Cytotoxic and genotoxic potential of Bulgarian Rosa alba L. essential oil – in vitro model study"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:24:33.185680+00:00"}