@article{oai:repo.qst.go.jp:00048763,
 author = {Jovtchev, Gabrielle and Stankov, Alexander and Georgieva, Almira and Dobreva, Anna and Bakalova, Rumiana and Aoki, Ichio and Mileva, Milka and バカロバ ルミアナ and 青木 伊知男},
 issue = {2},
 journal = {Biotechnology & Biotechnological Equipment},
 month = {Jan},
 note = {Background/Aim: Rose alba L. also known as the white oil-bearing rose, has been cultivated
in relatively small areas of Europe – predominantly in the Rose Valley of Bulgaria. The
essential rose oils of Rosa alba L. is among the most expensive products on the world
markets. In the last years, an increasing number of studies in vitro and in vivo, including
clinical studies, have demonstrated a therapeutic efficacy of rose oils. However, little is
known about the cytotoxic and genotoxic potential of the phytocomplex oil extract, derived
from Rosa alba L., and its constituents. The aim of the present work was to investigate
cytotoxicity and clastogenic effects of Rosa alba L. essential oil and its main constituents –
geraniol and citral. Methods: We used classical cytogenetic methods and comet assay. 1-
Methyl-3-nitro-1-nitrosoguanidine was used as a standard mutagen. Results: The data show
that Rose alba L. essential oil (in concentrations up to 1000 g/ml) did not exhibit a
statistically significant cytotoxic effect. The oil extract did not increase significantly the level
of mitotic disturbances (micronuclei and aneuploidy effects) and has no significant effect on the induction of chromatid aberrations, compared to the untreated control sample. Only
geraniol and citral (in concentrations used) increased significantly the percentage of migrated
DNA in the comet tail, compared to the whole oil extract. Conclusion: This study gives a
reason to believe that rose oils and some of their constituents have a potential as
supplementary components in anticancer therapy. They would be harmless to normal cells and
tissues, but with potential for additive or synergistic cytotoxicity against cancer cells.},
 title = {Cytotoxic and genotoxic potential of Bulgarian Rosa alba L. essential oil – in vitro model study},
 volume = {32},
 year = {2018}
}